Incidence and Risk Factors of Retinopathy of Prematurity in Khatam Al-Anbia Ophthalmology Hospital in Mashhad City

Document Type : Original Article

Authors

1 School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2 Retina Research Center, Department of Ophthalmology, Mashhad University of Medical Sciences, Mashhad, Iran

3 Eye Research Center, Khatam-al-Anbia Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

4 Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Background and aim: Retinopathy of prematurity (ROP) is a complex disease initiated by abnormal retinal vascularization in premature infants. ROP causes more than 10% of childhood blindness in developed countries and a preventable disease with determining its risk factors. Then it's necessary to resolve the incidence rate and risk factors of ROP in our area.
Materials and methods: In a retrospective study, all premature infants referred to the ROP clinic of Khatam Al-Anbia Ophthalmology hospital (April 2015- Sept 2016) recorded. Chi-Square Test analyzed qualitative data and quantitative data analyzed by T-test and ANOVA.
Results: Among 1247 premature infants there were 553, (44%) different stages of ROP. Data analysis showed a significant relationship between ROP and low birth weight (P value<0.0001), prematurity (P value<0.0001), NICU admission (P value<0.0001), oxygen therapy (P value<0.0001), multiple pregnancy (P value=0.049), surfactant therapy (P value=0.03). Gender (P value=0.52), gravid (P value=0.46) and type of delivery (P value=o.8) didn’t have significant relationship to ROP.
Conclusion: Among 1247 infants referred to Khatam Al-Anbia hospital, there were 553 (44%) different stages of ROP. According to the study, there is a significant relationship between ROP and variables such as low gestational age, low birth weight, NICU admission, receiving surfactant, and multiple pregnancies. There is no meaningful relationship between ROP and the gender, type of delivery, and gravid.

Keywords

Main Subjects


1. Bayat-Mokhtari M, Pishva N, Attarzadeh A, Hosseini H, Pourarian S. Incidence and Risk Factors of Retinopathy of Prematurity among Preterm Infants in Shiraz/Iran. Iranian journal of pediatrics. 2010;20(3):303-7.
2. Gilbert C. Retinopathy of prematurity--the "second lull"? The British journal of ophthalmology. 2001; 85(9):1017-9.
3. Gibson DL, Sheps SB, Schechter MT, Wiggins S, McCormick AQ. Retinopathy of prematurity: a new epidemic? Pediatrics. 1989; 83(4):486-92.
4. Raab EL, Aaby AA, Bloom JN, Edmond JC, Lueder GT, Olitsky SE, et al. Pediatric Ophthalmology and Strabismus. Weiss JS, editor: American Academy of Ophthalmology; 2012-2013.
5. Gilbert C. Characteristics of Infants With Severe Retinopathy of Prematurity in Countries With Low, Moderate, and High Levels of Development: Implications for Screening Programs. Pediatrics. 2005;115(5):e518-e25.
6. Ghaseminejad AK, Niknafs P, Distribution of Retinopathy of Prematurity and Its Risk Factors. Iranian journal of pediatrics.2011; 21(2):209-14.
7. Mansouri M, Hemmatpour S, Sedighiani F, Ghamari D, Chavoshi D.Factors associated with retinopathy of prematurity in hospitalized preterm infants in Sanandaj,Iran.Electronic Physicion. Sept 2016;8(9):2931-2934.
8. Stenson BJ. Oxygen targets for preterm infants. Neonatology.2013; 103(4):341-5.
9. Afarid M, Hosseini H, Abtahi B. Screening for retinopathy of prematurity in South of Iran. Middle East African Journal of Ophthalmology. 2012;19(3):277-81.
Volume 1, Issue 3
September 2019
Pages 36-39
  • Receive Date: 01 July 2019
  • Revise Date: 09 August 2019
  • Accept Date: 23 August 2019
  • First Publish Date: 01 September 2019