International Journal of Scientific Research in Dental and Medical Sciences

International Journal of Scientific Research in Dental and Medical Sciences

Atypical and Varied Presentations of Ameloblastoma: A Case Series

Document Type : Case Reports

Authors
Shilpi Rajiv Daveshwar 1
Hiral Samir Shah 2
Meena Rajiv Daveshwar 2
1 Department of Dentistry, GMERS Medical College Himmatnagar, Gujarat, India
2 Department of Pathology, Baroda Medical College, Gujarat, India
10.30485/ijsrdms.2025.534550.1671
Abstract
Ameloblastoma is a benign odontogenic tumor that exhibits local aggressiveness. Around 80% cases occur in the mandible, out of which the majority of cases are seen in the mandibular ramus region. Ameloblastoma presents as a non-symptomatic lesion and may be detected during routine radiographic examination. However, the diagnosis is confirmed by histopathological examination. In our case series, we report three cases of Ameloblastoma: one in the maxilla and two in the mandible, of which one was in the ramus region and the other in the anterior region. All lesions were confirmed by histopathological examination with immunohistochemical staining. Histologically, Ameloblastoma has multiple microscopic variants. In our study, we found a follicular variant in the maxilla, a desmoplastic variant in the mandibular ramus, and a follicular and plexiform (mixed) pattern in the anterior mandible. In all three cases, there were varied clinical and radiographic findings. Thus, histopathological examination is a crucial confirmatory tool for accurate diagnosis and effective treatment planning.
Keywords
Ameloblastoma
Jaw Neoplasms
Odontogenic Cysts

Subjects

[1] Astekar M, Rao R, Sanjai K, Sundaragiri KS, Sapra G, Sanjeevareddygari S, et al. Desmoplastic ameloblastoma: A multicentric study of 18 case series with literature review. Medical Reports. 2025;9:100148. https://doi.org/10.1016/j.hmedic.2024.100148.
[2] Buva K, Deshmukh A, Kavle P, Gupta A. An unusual case report of basal cell ameloblastoma and a detailed review of literature. Journal of Oral and Maxillofacial Pathology. 2022;26(2):291. https://doi.org/10.4103/jomfp.jomfp_95_22.
[3] El-Naggar AK, Chan JK, Takata T, Grandis JR, Slootweg PJ. The fourth edition of the head and neck World Health Organization blue book: editors' perspectives. Human pathology. 2017;66:10-2. https://doi.org/10.1016/j.humpath.2017.05.014.
[4] Ragunathan YT, Kumar SK, Janardhanam D, Ravi A, Santhanam V, Ramdas MN. Prevalence and epidemiological profile of ameloblastoma in India: a systematic review and meta-analyses. Asian Pacific Journal of Cancer Prevention: APJCP. 202223(11):3601-10. https://doi.org/10.31557/APJCP.2022.23.11.3601.
[5] Kajla P, Lata J, Aggarwal S. A combination of follicular and plexiform ameloblastoma: A rare case report. National Journal of Maxillofacial Surgery. 2022;13(Suppl 1):S212-5. https://doi.org/10.4103/njms.NJMS_82_16.
[6] Chavhan A, Pakhale A, Patil S, Hande A, Tehzeeb H, Akolkar S, et al. Ameloblastoma with the hybrid desmoplastic and plexiform pattern: a case report. Cureus. 2024;16(6). https://doi.org/10.7759/cureus.61686.
[7] Urechescu H, Banu A, Baderca F, Closca RM, Ilas-Tat MB, Urtila F, et al. Ameloblastoma of the Mandible in a 16-Year-Old Female—Case Report. Medicina. 2023;60(1):66. https://doi.org/10.3390/medicina60010066.
[8] Sriram S, Hasan S, Jayakanth M, Ahmad SA, Narayanan AK. Granular cell ameloblastoma: A rare case report with public health implications. Medicine. 2025;104(19):e41992. https://doi.org/10.1097/MD.0000000000041992.
[9] Mortazavi H, Baharvand M, Safi Y. Scalloped border as a possible diagnostic aid for differentiating jaw lesions: A pictorial essay. Imaging Science in Dentistry. 2022;52(3):309-17. https://doi.org/10.5624/isd.20220033.
[10] Jain S, Gokkulakrishnan S. Ameloblastoma of the Mandible: A Case Series. Journal of Dental Sciences and Oral Rehabilitation. 2024;15(2):34.
[11] Al-Sebaei MO, Almazrooa SA, Akeel SK, Sawan AS, Gomaa WM. Clinicopathologic Characteristics of Ameloblastoma with Immunohistochemical Study. Journal of Research in Medical and Dental Science. 2022;10(7):79‑86.
[12] Goh YC, Siriwardena BS, Tilakaratne WM. Association of clinicopathological factors and treatment modalities in the recurrence ofameloblastoma: analysis of 624 cases. Journal of Oral Pathology & Medicine. 2021;50(9):927-36. https://doi.org/10.1111/jop.13228.
[13] Chintamaneni Raja Lakshmi, Sujana Mulk Bhavana, Sai Madhavi Nallamilli, Meka Poorna Venkata Prabhat, Gummadapu Sarat, Chennupati Anuradha. Hybrid ameloblastoma of the maxilla: a puzzling pathology. Iranian Journal of Medical Sciences. 2016;41(4):340-44.
[14] Alarjani MM. An unusual case report of unicystic ameloblastoma of the mandible. Journal of Pharmacy and Bioallied Sciences. 2024;16(Suppl 1):S955-9. https://doi.org/10.4103/jpbs.jpbs_568_23.
[15] Saxena N, Choudhary SH, Aldhuwayhi SD, Thakare A. Infected multilocular unicystic ameloblastoma involving ramus and coronoid process: A rare case report. Contemporary Clinical Dentistry. 2020;11(2):179-83. https://doi.org/ 10.4103/ccd.ccd_315_20.
[16] Kalmegh PP, Hande AH, Gawande MN, Patil SK, Sonone AM, Hande A, et al. Unicystic ameloblastoma (UA): a case series. Cureus. 2022;14(11). https://doi.org/10.7759/cureus.31039.
[17] Schoinohoriti O, Tsami C, Karathanasi V, Kolomvos N. Mixed-Pattern Ameloblastoma of the Anterior Mandible: A Rare Histopathological Presentation at an Infrequent Location. Cureus. 2023;15(8):e42840. https://doi.org/10.7759/cureus.42840.
[18] Fukumashi K, Enokiya Y, Inoue T. Cytokeratins expression of constituting cells in ameloblastoma. The Bulletin of Tokyo Dental College. 2002;43(1):13-21. https://doi.org/10.2209/tdcpublication.43.13.
International Journal of Scientific Research in Dental and Medical Sciences
Volume 7, Issue 3
Summer 2025
Pages 131-134

  • Receive Date 14 June 2025
  • Revise Date 24 August 2025
  • Accept Date 29 August 2025
  • Publish Date 01 September 2025