International Journal of Scientific Research in Dental and Medical Sciences

International Journal of Scientific Research in Dental and Medical Sciences

Evaluating the Effect of Metal Nanoparticles in the Treatment of Peri-implantitis: A Systematic Review and Meta-analysis

Document Type : Review Article

Authors
Shima Firouzi 1
Fatemeh Zahra Kalakijuybari 2
Maryam Afrasiabi 3
Shakila Peymani 4
1 Department of Prosthodontics, School of Dentistry, Dental Research Center, Avicenna Institute of Clinical Sciences, Avicenna Health Research Institute, Hamadan University of Medical Sciences, Hamadan, Iran
2 Department of Prosthodontics, School of Dentistry, Babol University of Medical Sciences, Babol, Iran
3 Independent Researcher, Tehran, Iran
4 Department of Oral and Maxillofacial Surgery, School of Dentistry, Alborz University of Medical mSciences, Karaj, Iran
10.30485/ijsrdms.2025.538322.1673
Abstract
Background and aim: Plaque-related pathological conditions such as peri-implantitis (PI) affect the tissues surrounding dental implants and affect the survival of implants. Hence, treatment of PI is of great importance, but bacterial resistance has been observed with antibiotics. Hence, the use of nanoparticles has been proposed. The present study aimed to evaluate the effect of metal nanoparticles (silver nanoparticles) in the treatment of peri-implantitis.
Material and methods: The international databases PubMed, EMBASE, and Web of Science were searched using keywords aligned with the study objective up to July 2025. Two blinded, independent authors reviewed all articles. STATA/MP. v17 (College Station, Texas, USA) was used to perform the analyses.
Results: In the present study, fifteen in vitro studies were included. Antibacterial activity of AgNPs in dental implants was 60% (ES: 0.60; 95% CI, 0.54, 0.67). The effectiveness of AgNPs for the treatment of peri-implantitis was 73% (ES: 0.73; 95% CI, 0.66, 0.81).

Conclusions: The present study showed acceptable effectiveness of silver nanoparticles' antibacterial activity and reduction of inflammatory factors in the treatment of PI.
Keywords
Metal Nanoparticles
Nanoparticles
Peri-Implantitis

Subjects

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International Journal of Scientific Research in Dental and Medical Sciences
Volume 7, Issue 3
Summer 2025
Pages 110-116

  • Receive Date 25 June 2025
  • Revise Date 04 August 2025
  • Accept Date 11 August 2025
  • Publish Date 01 September 2025