International Journal of Scientific Research in Dental and Medical Sciences

International Journal of Scientific Research in Dental and Medical Sciences

Cytodiagnosis of Extramedullary Leukemic Infiltration: A series of Nine Cases

Document Type : Case Reports

Authors
Swati Diwakar
Gunja Dwivedi
Priya Parmar
Anju Mishra
Department of Pathology, Rabindranath Tagore Medical College, Udaipur, India
10.30485/ijsrdms.2025.497119.1631
Abstract
Nine cases of extramedullary leukemic infiltration were examined using fine-needle aspiration cytology (FNAC), focusing on clinical presentations, cytological findings, and hematological diagnoses. The cases included chronic myeloid leukemia (CML) and acute leukemia, with extramedullary sites such as lymph nodes, skin, pleural fluid, and soft tissue affected. FNAC smears commonly showed scattered granulocytic precursor cells, blasts, and mature neutrophils. One case presented with malignant pleural effusion. The cytological features helped distinguish leukemic infiltration from lymphoma, although challenges arose when FNAC was used without considering the full hematological context. The study concluded that extramedullary leukemic infiltration can occur at various stages and locations, and FNAC is an effective diagnostic tool when combined with peripheral smear examination and patient history. This emphasizes the importance of comprehensive monitoring and interdisciplinary collaboration for accurate diagnosis and treatment planning in these cases.
Keywords
Cytology
Hematopoiesis
Leukemic Infiltration

Subjects

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International Journal of Scientific Research in Dental and Medical Sciences
Volume 7, Issue 1
Winter 2025
Pages 43-47

  • Receive Date 02 January 2025
  • Revise Date 16 February 2025
  • Accept Date 27 February 2025
  • Publish Date 07 March 2025