International Journal of Scientific Research in Dental and Medical Sciences

International Journal of Scientific Research in Dental and Medical Sciences

Evaluation of the Antimicrobial Effects of Mesoporous Silica Nanoparticles Carrying Nanosilver for Endodontic Treatment: A Systematic Review and Meta-analysis

Document Type : Review Article

Authors
Faezeh Niroumandfar 1
Zahra Fathi 2
Sara Karami Amidabadi 3
Samane Ahmadi 4
1 School of Dentistry, Islamic Azad University, Isfahan (Khorasgan) Branch, Isfahan, Iran
2 Department of Endodontics, School of Dentistry, Islamic Azad University, Tabriz Branch, Tabriz, Iran
3 School of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran
4 Department of Endodonticss, Faculty of Dentistry, Zanjan University of Medical Sciences, Zanjan, Iran
10.30485/ijsrdms.2025.511467.1647
Abstract
Background and aim: The present study aimed to evaluate the antimicrobial effects of mesoporous silica nanoparticles carrying nanosilver in endodontic treatment.
Material and methods: The literature was screened via international databases Cochrane, Embase, and MEDLINE (PubMed and Ovid) up to October 2024 with English language restriction. Two reviewers independently performed screening and evaluation of articles. The ToxRTool® checklist information contained eighteen items to evaluate Methodological quality. The mean difference was used as an effect size indicator to analyze each included study. The random-effect model combined the effect size with the Restricted maximum likelihood method. All meta-analyses were performed using Stata software (version 17).
Results: A total of 143 articles were retrieved from all the databases; after applying eligibility criteria, eight studies were included. Biofilm was significantly lower in the nMS-nAg groups compared to the control group (MD: -64.94 95% CI; -76.43,-53,44; P˂0.001).
Conclusions: Based on the present meta-analysis, nMS-nAg-Chx showed strong antibacterial activity to reduce biofilms.
Keywords
Anti-Bacterial Agents
Endodontics
Nanoparticles
Silicon Dioxide
Silver

Subjects

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International Journal of Scientific Research in Dental and Medical Sciences
Volume 7, Issue 1
Winter 2025
Pages 29-34

  • Receive Date 21 December 2024
  • Revise Date 09 February 2025
  • Accept Date 27 February 2025
  • Publish Date 05 March 2025