International Journal of Scientific Research in Dental and Medical Sciences

International Journal of Scientific Research in Dental and Medical Sciences

Evaluation of the Effects of ZnONPs, Standard AgNPs, and Im-AgNPs Nanoparticles on the Microhardness of Root Canal Dentin: A Systematic Review and Meta-analysis

Document Type : Review Article

Authors
Samane Ahmadi 1
Seyedeh Sana Zamiri 2
Samin Sedghi 3
Sara Karami Amidabadi 4
Milad Moradi 5
1 Department of Endodonticss, Faculty of Dentistry, Zanjan University of Medical Sciences, Zanjan, Iran
2 School of Dentistry, Islamic Azad University, Tehran Branch, Tehran, Iran
3 Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
4 School of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran
5 Department of Endodontics, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
10.30485/ijsrdms.2025.506747.1639
Abstract
Background and aim: The present study aimed to evaluate the effect of  Zinc Oxide (ZnONPs), Standard Silver(AgNPs), and Imidazolium-based Silver (Im-AgNPs) nanoparticles on the microhardness of root canal dentin.
Material and methods: The literature was screened via international databases Cochrane, Embase, and MEDLINE (PubMed and Ovid) up to October 2024 with English language restriction. Two reviewers independently performed screening and evaluation of articles. The ToxRTool® checklist information contained eighteen items to evaluate Methodological quality. The mean difference was used as an effect size indicator to analyze each included study. The fixed-effect model with the Inverse–variance method combined the effect size. All meta-analyses were performed using Stata software (version 17).
Results: A total of 219 articles were retrieved from all the databases; after applying eligibility criteria, seven studies were included. Immersion in standard AgNP irrigant significantly increased the VHN compared to the control group in the coronal (MD: 16.13 95% CI; 15.39-16.86; P˂0.001). Immersion in Im-AgNPs significantly increased the VHN in the middle (MD: 6.60 95% CI; 1.90-11.31; P˂0.05) and apical  (MD: 10.25 95% CI; 5.78-14.72; P˂0.001). ZnONPs irrigant increased the VHN, compared to the control group in the coronal (MD: 10.92 95% CI; 10.13-11.71; P˂0.001).
Conclusions: Based on the present meta-analysis, root canal irrigants containing ZnONPs, Standard AgNPs, and Im-AgNPs can improve the microhardness of root canal dentin in coronal, middle, and apical regions.
Keywords
Endodontics
Nanoparticles
Root Canal Irrigants

Subjects

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International Journal of Scientific Research in Dental and Medical Sciences
Volume 6, Issue 4
Autumn 2024
Pages 199-207

  • Receive Date 05 September 2024
  • Revise Date 26 October 2024
  • Accept Date 20 November 2024
  • Publish Date 30 November 2024