International Journal of Scientific Research in Dental and Medical Sciences

International Journal of Scientific Research in Dental and Medical Sciences

Coexistence of Carcinoma and Granulomatous Inflammation in Breast and Axillary Lymph Nodes: A Case Reports

Document Type : Case Reports

Authors
Nishtha Nishtha
Namita Goyal
Department of Pathology, Rabindranath Tagore Medical College, Udaipur, Rajasthan, India
10.30485/ijsrdms.2025.488046.1614
Abstract
Breast carcinoma is the most common malignancy and leading cause of cancer-related deaths in women worldwide. However, breast carcinoma with an associated granulomatous inflammation in the same breast and axillary lymph nodes is unusual. This simultaneous occurrence of both diseases can complicate the neoplastic process. We present a series of four cases of invasive breast carcinoma with an associated granulomatous reaction in the breast and ipsilateral axillary lymph nodes. It is seen that axillary lymph node enlargement in cases of breast carcinoma is not always caused by metastasis of cancer. Various granulomatous lesions are Tuberculosis, sarcoidosis, brucellosis, foreign body reactions, cat scratch disease, lymphoma, and AIDS. It can also cause axillary lymphadenopathy. The presence of granulomas in association with malignancies should be further evaluated, particularly in regions with a high prevalence of Tuberculosis in developing countries like India, for the possibility of coexistent Tuberculosis, as this may alter the postoperative management and prognosis of the patient. Accurate diagnosis is crucial for downstaging breast carcinoma, identifying curable cases, and enabling effective management of both conditions.
Keywords
Carcinoma
Granulomatous Disease
Tuberculosis

Subjects

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International Journal of Scientific Research in Dental and Medical Sciences
Volume 6, Issue 4
Autumn 2024
Pages 208-212

  • Receive Date 10 October 2024
  • Revise Date 11 November 2024
  • Accept Date 19 November 2024
  • Publish Date 26 November 2024