International Journal of Scientific Research in Dental and Medical Sciences

International Journal of Scientific Research in Dental and Medical Sciences

Evaluating the Effectiveness and Stability of Regenerative Treatment and Orthodontic Tooth Movement in Stage IV Periodontitis: A Systematic Review and Meta-analysis

Document Type : Review Article

Authors
1 Department of Periodontics, School of Dentistry, Urmia University of Medical Sciences, Urmia, Iran
2 Department of Pediatric Dentistry, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
3 Department of Public Health, UFR of Medicine and Paramedical Professions, Clermont Auvergne University, France
4 Department of Prosthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran
5 Department of Periodontics, School of of Dentistry, Centro Escolar University, Manila, Philippines
6 Independent Researcher, Tehran, Iran
Abstract
Background and aim: The present systematic review and meta-analysis aimed to evaluate the effectiveness and stability of regenerative treatment and orthodontic tooth movement in stage IV periodontitis.
Material and methods: For the present systematic review and meta-analysis study, international databases such as MEDLINE (PubMed and Ovid), Web of Science, and Scopus were searched until October 2024 using keywords relevant to the study objectives. STATA/MP. v17 software was used to analyze data.
Results: The present study included ten studies. The present meta-analysis showed a mean reduction of 1.10 mm in probing depth (95% CI, -1.18mm, -1.03mm; P < 0.001), an attachment gain of 1.96 mm (95% CI, -2.13mm,1.78mm; P < 0.001), and radiographic bone level of -1.44 mm ( 95% CI -1.65mm, -1.22mm; p<0.001).
Conclusions: According to the one-year results of the present meta-analysis, an interdisciplinary approach can produce favorable and stable outcomes in motivated and cooperative patients with stage IV periodontitis who require orthodontic treatment.
Keywords

Subjects


[1] Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, Fine DH, et al. Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions. Journal of periodontology. 2018;89:S173-82. https://doi.org/10.1002/JPER.17-0721.
[2] Wang B. Topical Therapy for Periodontal Disease: intra-pocket delivery of biomolecules. 2020.
[3] Hirschfeld J, Reichardt E, Sharma P, Hilber A, Meyer-Marcotty P, Stellzig-Eisenhauer A, et al. Interest in orthodontic tooth alignment in adult patients affected by periodontitis: A questionnaire‐based cross‐sectional pilot study. Journal of periodontology. 2019;90(9):957-65. https://doi.org/10.1002/JPER.18-0578.
[4] Papageorgiou SN, Antonoglou GN, Michelogiannakis D, Kakali L, Eliades T, Madianos P. Effect of periodontal–orthodontic treatment of teeth with pathological tooth flaring, drifting, and elongation in patients with severe periodontitis: A systematic review with meta‐analysis. Journal of Clinical Periodontology. 2022;49:102-20. https://doi.org/10.1111/jcpe.13529.
[5] Kloukos D, Roccuzzo A, Stähli A, Sculean A, Katsaros C, Salvi GE. Effect of combined periodontal and orthodontic treatment of tilted molars and of teeth with intra‐bony and furcation defects in stage‐IV periodontitis patients: A systematic review. Journal of clinical periodontology. 2022 Jun;49:121-48. https://doi.org/10.1111/jcpe.13509.
[6] Tietmann C, Bröseler F, Axelrad T, Jepsen K, Jepsen S. Regenerative periodontal surgery and orthodontic tooth movement in stage IV periodontitis: A retrospective practice‐based cohort study. Journal of Clinical Periodontology. 2021;48(5):668-78. https://doi.org/10.1111/jcpe.13442.
[7] Jepsen K, Tietmann C, Kutschera E, Wüllenweber P, Jäger A, Cardaropoli D, et al. The effect of timing of orthodontic therapy on the outcomes of regenerative periodontal surgery in patients with stage IV periodontitis: A multicenter randomized trial. Journal of Clinical Periodontology. 2021;48(10):1282-92. https://doi.org/10.1111/jcpe.13528.
[8] Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. bmj. 2021;372. https://doi.org/10.1136/bmj.n71.
[9] Peterson J, Welch V, Losos M, Tugwell PJ. The Newcastle-Ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa: Ottawa Hospital Research Institute. 2011;2(1):1-2.
[10] Higgins JP, Savović J, Page MJ, Elbers RG, Sterne JA. Assessing risk of bias in a randomized trial. Cochrane handbook for systematic reviews of interventions. 2019:205-28. https://doi.org/10.1002/9781119536604.ch8.
[11] Dung SZ, Tzeng IS, Li CS. Immediate orthodontic treatment after regeneration of periodontal intrabony defects: A long-term retrospective study. Journal of Dental Sciences. 2024;20(1):417-27. https://doi.org/10.1016/j.jds.2024.06.003.
[12] Tietmann C, Jepsen S, Kauer R, Jepsen K. Clinical effectiveness of regenerative periodontal surgery and orthodontic tooth movement with clear aligners in stage IV periodontitis: a case series. Quintessence International. 2024;55(5):348. https://doi.org/10.3290/j.qi.b5213521.
[13] Jepsen K, Tietmann C, Martin C, Kutschera E, Jäger A, Wüllenweber P, et al. Synergy of regenerative periodontal surgery and orthodontics improves quality of life of patients with stage IV periodontitis: 24-month outcomes of a multicenter RCT. Bioengineering. 2023;10(6):695. https://doi.org/10.3390/bioengineering10060695.
[14] Tietmann C, Jepsen S, Heibrok H, Wenzel S, Jepsen K. Long-term stability of regenerative periodontal surgery and orthodontic tooth movement in stage IV periodontitis: 10‐year data of a retrospective study. Journal of Periodontology. 2023;94(10):1176-86. https://doi.org/10.1002/JPER.23-0081.
[15] Tu CC, Lo CY, Chang PC, Yin HJ. Orthodontic treatment of periodontally compromised teeth after periodontal regeneration: A restrospective study. Journal of the Formosan Medical Association. 2022;121(10):2065-73. https://doi.org/10.1016/j.jfma.2022.02.021.
[16] Aimetti M, Garbo D, Ercoli E, Grigorie MM, Citterio F, Romano F. Long-Term Prognosis of Severely Compromised Teeth Following Combined Periodontal and Orthodontic Treatment: A Retrospective Study. International Journal of Periodontics & Restorative Dentistry. 2020;40(1):94. https://doi.org/10.11607/prd.4523.
[17] Jiao J, Xin TY, Shi J, Meng HX. Evaluation of periodontal status after orthodontic treatment: a pilot study on patients with stage IV/Grade C periodontitis. Chin J Dent Res. 2019;22(4):229-39. https://doi.org/10.3290/j.cjdr.a43734.
[18] Cao T, Xu L, Shi J, Zhou Y. Combined orthodontic-periodontal treatment in periodontal patients with anteriorly displaced incisors. American Journal of Orthodontics and Dentofacial Orthopedics. 2015;148(5):805-13. https://doi.org/10.1016/j.ajodo.2015.05.026.
[19] Paolone MG, Kaitsas R. Orthodontic-periodontal interactions: Orthodontic extrusion in interdisciplinary regenerative treatments. International Orthodontics. 2018;16(2):217-45. https://doi.org/10.1016/j.ortho.2018.03.019.
[20] Attia MS, Hazzaa H, Al-Aziz FA, Elewa GM. Evaluation of adjunctive use of low-level diode laser biostimulation with combined orthodontic regenerative therapy. J Int Acad Periodontol. 2019;21(2):63-73.
[21] Stelzel MJ, Flores-de-Jacoby L. Guided tissue regeneration in a combined periodontal and orthodontic treatment: a case report. International Journal of Periodontics & Restorative Dentistry. 1998;18(2):188.
[22] Li Y, Zhan Q, Bao M, Yi J, Li Y. Biomechanical and biological responses of periodontium in orthodontic tooth movement: up-date in a new decade. International journal of oral science. 2021;13(1):20. https://doi.org/10.1038/s41368-021-00125-5.
[23] Wiegand C, White R. Microdeformation in wound healing. Wound Repair and Regeneration. 2013;21(6):793-9. https://doi.org/10.1111/wrr.12111.
[24] Vining KH, Mooney DJ. Mechanical forces direct stem cell behaviour in development and regeneration. Nature reviews Molecular cell biology. 2017;18(12):728-42. https://doi.org/10.1038/nrm.2017.108.
[25] Alghamdi B, Jeon HH, Ni J, Qiu D, Liu A, Hong JJ, et al. Osteoimmunology in periodontitis and orthodontic tooth movement. Current osteoporosis reports. 2023;21(2):128-46. https://doi.org/10.1007/s11914-023-00774-x.
[26] Botelho J, Machado V, Proença L, Bellini DH, Chambrone L, Alcoforado G, et al. The impact of nonsurgical periodontal treatment on oral health-related quality of life: a systematic review and meta-analysis. Clinical Oral Investigations. 2020;24(2):585-96. https://doi.org/10.1007/s00784-019-03188-1.
[27] Ozcelik O, Haytac MC, Seydaoglu G. Immediate post‐operative effects of different periodontal treatment modalities on oral health‐related quality of life: a randomized clinical trial. Journal of clinical periodontology. 2007;34(9):788-96. https://doi.org/10.1111/j.1600-051X.2007.01120.x.
[28] Shanbhag S, Dahiya M, Croucher R. The impact of periodontal therapy on oral health‐related quality of life in adults: a systematic review. Journal of clinical periodontology. 2012;39(8):725-35. https://doi.org/10.1111/j.1600-051X.2012.01910.x.
[29] Ribeiro LG, Antunes LS, Küchler EC, Baratto-Filho F, Kirschneck C, Guimaraes LS, et al. Impact of malocclusion treatments on Oral Health-Related Quality of Life: An overview of systematic reviews. Clinical Oral Investigations. 2023;27(3):907-32. https://doi.org/10.1007/s00784-022-04837-8.
Volume 6, Issue 4
Autumn 2024
Pages 192-198

  • Receive Date 02 October 2024
  • Revise Date 12 November 2024
  • Accept Date 21 November 2024
  • Publish Date 29 November 2024