International Journal of Scientific Research in Dental and Medical Sciences

International Journal of Scientific Research in Dental and Medical Sciences

Evaluation of the Effect of Using Adipose Stem Cells in Bone Augmentation in Patients with Jaw Bone Atrophy: A Systematic Review and Meta-analysis

Document Type : Review Article

Authors
Hassina Shadab 1
Mohammad Eissa Ahmadi 1
Sajeya Karimi 1
Marzia Moez 2
Amena Waziri 1
1 Department of Periodontics, School of Dentistry, Kabul University of Medical Sciences, Kabul, Afghanistan
2 Department of Oral and Maxillofacial Surgery, School of Dentistry, Kabul University of Medical Sciences, Kabul, Afghanistan
10.30485/ijsrdms.2024.466880.1595
Abstract
Background and aim: Alveolar ridge bone augmentation is required for patients receiving dental implant therapy who have atrophy of the jaw bone. The latter method does not require bone harvesting, which makes it less invasive during surgery. However, it is not always successful in producing enough bone for dental implant therapy because it does not ensure local osteoblast differentiation and blood flow from surrounding tissues. This research aims to assess the impact of bone augmentation with adipose stem cells in patients with atrophy of the jaw bone.
Material and methods: The use of Google Scholar and international databases like PubMed, Web of Science, Scopus, Sites Direct, Elsevier, and Wiley was necessary to find published articles and scientific proof regarding the impact of adipose stem cell therapy on bone augmentation in patients suffering from atrophy of the jaw bone; the search period was until June 2024. Data were analyzed using STATA software, Version 17. The effect size was measured with a 95% confidence interval (CI), and a fixed effect model and inverse variance method were used.
Results: Six studies were reviewed. The six-month survival rate was 79% (ES 95% CI: 0.10-1.47). The survival rate of augmented bone in patients in the ASCs+ group following jawbone augmentation with bone substitutes containing adipose stem cells was significantly higher (P < 0.01) than in the ASCs group.
Conclusions: According to the results, patients with jaw bone atrophy may benefit from using ASCs for bone augmentation on the alveolar ridge.
Keywords
Bone Substitutes
Dental Implants
Mesenchymal Stem Cells
Survival Rate

Subjects

[1] Rickert D, Sauerbier S, Nagursky H, Menne D, Vissink A, Raghoebar GM. Maxillary sinus floor elevation with bovine bone mineral combined with either autogenous bone or autogenous stem cells: a prospective randomized clinical trial. Clinical oral implants research. 2011;22(3):251-8. https://doi.org/10.1111/j.1600-0501.2010.01981.x.
[2] Bagge J, Berg LC, Janes J, MacLeod JN. Donor age effects on in vitro chondrogenic and osteogenic differentiation performance of equine bone marrow-and adipose tissue-derived mesenchymal stromal cells. BMC Veterinary Research. 2022;18(1):388. https://doi.org/10.1186/s12917-022-03475-2.
[3] Ohya M, Yamada Y, Ozawa R, Ito K, Takahashi M, Ueda M. Sinus floor elevation applied tissue‐engineered bone: Comparative study between mesenchymal stem cells/platelet‐rich plasma (PRP) and autogenous bone with PRP complexes in rabbits. Clinical oral implants research. 2005;16(5):622-9. https://doi.org/10.1111/j.1600-0501.2005.01136.x.
[4] Tobita M, Uysal AC, Ogawa R, Hyakusoku H, Mizuno H. Periodontal tissue regeneration with adipose-derived stem cells. Tissue Engineering Part A. 2008;14(6):945-53. https://doi.org/10.1089/ten.tea.2007.0048.
[5] Citterio F, Gualini G, Fierravanti L, Aimetti M. Stem cells and periodontal regeneration: present and future. Plastic and Aesthetic Research. 2020;7:41. https://doi.org/10.20517/2347-9264.2020.29.
[6] Zuk PA, Zhu MI, Mizuno H, Huang J, Futrell JW, Katz AJ, Benhaim P, Lorenz HP, Hedrick MH. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue engineering. 2001;7(2):211-28. https://doi.org/10.1089/107632701300062859.
[7] JL D. Bone induction by BMP-2 transduced stem cells derived from human fat. J Orthop Res. 2003;21:622-9.
[8] Dirzu N, Lucaciu O, Dirzu DS, Soritau O, Cenariu D, Crisan B, Tefas L, Campian RS. BMP-2 delivery through liposomes in bone regeneration. Applied Sciences. 2022;12(3):1373. https://doi.org/10.3390/app12031373.
[9] Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H, Alfonso ZC, Fraser JK, Benhaim P, Hedrick MH. Human adipose tissue is a source of multipotent stem cells. Molecular biology of the cell. 2002;13(12):4279-95. https://doi.org/10.1091/mbc.e02-02-0105.
[10] Smakaj A, De Mauro D, Rovere G, Pietramala S, Maccauro G, Parolini O, Lattanzi W, Liuzza F. Clinical Application of Adipose Derived Stem Cells for the Treatment of Aseptic Non-Unions: Current Stage and Future Perspectives—Systematic Review. International Journal of Molecular Sciences. 2022;23(6):3057. https://doi.org/10.3390/ijms23063057.
[11] Labusca L. Adipose tissue in bone regeneration-stem cell source and beyond. World Journal of Stem Cells. 2022;14(6):372-92. https://doi.org/10.4252%2Fwjsc.v14.i6.372.
[12] Lendeckel S, Jödicke A, Christophis P, Heidinger K, Wolff J, Fraser JK, Hedrick MH, Berthold L, Howaldt HP. Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: case report. Journal of Cranio-Maxillofacial Surgery. 2004;32(6):370-3. https://doi.org/10.1016/j.jcms.2004.06.002.
[13] Farré-Guasch E, Prins HJ, Overman JR, Ten Bruggenkate CM, Schulten EA, Helder MN, Klein-Nulend J. Human maxillary sinus floor elevation as a model for bone regeneration enabling the application of one-step surgical procedures. Tissue Engineering Part B: Reviews. 2013;19(1):69-82. https://doi.org/10.1089/ten.teb.2012.0404.
[14] Prins HJ, Schulten EA, Ten Bruggenkate CM, Klein-Nulend J, Helder MN. Bone regeneration using the freshly isolated autologous stromal vascular fraction of adipose tissue in combination with calcium phosphate ceramics. Stem cells translational medicine. 2016;5(10):1362-74. https://doi.org/10.5966/sctm.2015-0369.
[15] Minozzi S, Cinquini M, Gianola S, Gonzalez-Lorenzo M, Banzi R. The revised Cochrane risk of bias tool for randomized trials (RoB 2) showed low interrater reliability and challenges in its application. Journal of clinical epidemiology. 2020;126:37-44. https://doi.org/10.1016/j.jclinepi.2020.06.015.
[16] Wells GA, Shea B, O’Connell D, Peterson J, Welch V, Losos M, Tugwell P. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2000.
[17] Kizu Y, Ishii R, Matsumoto N, Saito I. Retrospective study on the effect of adipose stem cell transplantation on jaw bone regeneration. International Journal of Implant Dentistry. 2024;10(1):3. https://doi.org/10.1186/s40729-024-00523-4.
[18] Wu V, Klein-Nulend J, Bravenboer N, Ten Bruggenkate CM, Helder MN, Schulten EA. Long-term safety of bone regeneration using autologous stromal vascular fraction and calcium phosphate ceramics: a 10-year prospective cohort study. Stem cells translational medicine. 2023;12(9):617-30. https://doi.org/10.1093/stcltm/szad045.
[19] Asahina I, Kagami H, Agata H, Honda MJ, Sumita Y, Inoue M, Nagamura-Inoue T, Tojo A. Clinical outcome and 8-year follow-up of alveolar bone tissue engineering for severely atrophic alveolar bone using autologous bone marrow stromal cells with platelet-rich plasma and β-tricalcium phosphate granules. Journal of Clinical Medicine. 2021;10(22):5231. https://doi.org/10.3390/jcm10225231.
[20] Farré-Guasch E, Bravenboer N, Helder MN, Schulten EA, Ten Bruggenkate CM, Klein-Nulend J. Blood vessel formation and bone regeneration potential of the stromal vascular fraction seeded on a calcium phosphate scaffold in the human maxillary sinus floor elevation model. Materials. 2018;11(1):161. https://doi.org/10.3390/ma11010161.
[21] Sohrabi M, Hassani A, Karimi A, Momeni M, Bahrami N. Efficacy of adipose-derived stem cells for regeneration of localized mandibular bone defects. Journal of Craniomaxillofacial Research. 2016;3(1):151-6.
[22] Strong AL, Strong TA, Rhodes LV, Semon JA, Zhang X, Shi Z, Zhang S, Gimble JM, Burow ME, Bunnell BA. Obesity associated alterations in the biology of adipose stem cells mediate enhanced tumorigenesis by estrogen dependent pathways. Breast Cancer Research. 2013;15:1-5. https://doi.org/10.1186/bcr3569.
[23] T Tozawa K, Ono-Uruga Y, Yazawa M, Mori T, Murata M, Okamoto S, Ikeda Y, Matsubara Y. Megakaryocytes and platelets from a novel human adipose tissue–derived mesenchymal stem cell line. Blood, The Journal of the American Society of Hematology. 2019;133(7):633-43. https://doi.org/10.1182/blood-2018-04-842641.
[24] Ono Y, Wang Y, Suzuki H, Okamoto S, Ikeda Y, Murata M, Poncz M, Matsubara Y. Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/Maf. Blood, The Journal of the American Society of Hematology. 2012;120(18):3812-21. https://doi.org/10.1182/blood-2012-02-413617.
[25] Mishima K, Inoue H, Nishiyama T, Mabuchi Y, Amano Y, Ide F, Matsui M, Yamada H, Yamamoto G, Tanaka J, Yasuhara R. Transplantation of side population cells restores the function of damaged exocrine glands through clusterin. Stem cells. 2012;30(9):1925-37. https://doi.org/10.1002/stem.1173.
[26] Kikuta S, Tanaka N, Kazama T, Kazama M, Kano K, Ryu J, Tokuhashi Y, Matsumoto T. Osteogenic effects of dedifferentiated fat cell transplantation in rabbit models of bone defect and ovariectomy-induced osteoporosis. Tissue Engineering Part A. 2013;19(15-16):1792-802. https://doi.org/10.1089/ten.tea.2012.0380.
[27] Barba M, Di Taranto G, Lattanzi W. Adipose-derived stem cell therapies for bone regeneration. Expert Opinion on Biological Therapy. 2017;17(6):677-89. https://doi.org/10.1080/14712598.2017.1315403.
 
International Journal of Scientific Research in Dental and Medical Sciences
Volume 6, Issue 3
Summer 2024
Pages 128-133

  • Receive Date 03 July 2024
  • Revise Date 15 August 2024
  • Accept Date 24 August 2024
  • Publish Date 30 August 2024