International Journal of Scientific Research in Dental and Medical Sciences

International Journal of Scientific Research in Dental and Medical Sciences

Flow cytometric Analysis of Acute Promyelocytic Leukemia: A Series of Four Cases with Review of Literature

Document Type : Case Reports

Authors
Department of Pathology, RNT Medical College, Udaipur, Rajasthan, India
Abstract
Acute Promyelocytic Leukemia (APL) is an aggressive form of Acute Myeloid Leukemia (AML), a cancer of the bone marrow. APL causes accumulation of promyelocytes in the peripheral blood and bone marrow and is associated with translocation t(15; 17). The diagnosis of APL can be made with the help of a complete blood count, peripheral blood film examination, bone marrow, and flow cytometry. Immunophenotypically, APL is characterized by positivity for CD117 and cMPO, bright positivity for CD33 and CD13, and negative for CD34 and HLA-DR. Here, we present four cases suspected of acute leukemia on peripheral blood film and bone marrow examination and diagnosed as APL in flow cytometric analysis.
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Subjects


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Volume 6, Issue 2
Spring 2024
Pages 94-98

  • Receive Date 07 May 2024
  • Revise Date 02 June 2024
  • Accept Date 06 June 2024
  • Publish Date 09 June 2024