International Journal of Scientific Research in Dental and Medical Sciences

International Journal of Scientific Research in Dental and Medical Sciences

Sebaceous Carcinoma with Widespread Metastases: A Case Report

Document Type : Case Reports

Authors
Ningthoujam Dinita Devi 1
Rahul Mahawar 1
Sarmila Longjam 1
Laishram Jaichand Singh 1
Haobijam Persy 2
1 Department of Radiation Oncology, Regional Institute of Medical Sciences, Manipur, India
2 Department of Pathology, Regional Institute of Medical Sciences, Manipur, India
10.30485/ijsrdms.2024.451840.1575
Abstract
Sebaceous carcinoma (SC) is an infrequently encountered skin malignancy noted for its aggressive nature. We report here a 78-year-old male who presented to the Department of Radiation Oncology at RIMS Imphal with a two-month history of painless ulcerated swellings on the scalp, right ring finger, right big toe, and upper back, each measuring approximately 2x2cm2 with erythematous discoloration, hard, tender and adherent to the underlying structures. The histopathological study confirmed the lesion as sebaceous carcinoma. Palliative radiotherapy was administered. The patient responded favorably to the prescribed treatment regimen, resulting in a substantial 50% reduction in tumor size.
Consequently, regular follow-up monitoring was strongly recommended to ensure continued progress and optimal patient condition management. Early detection of this tumor is imperative for improved prognosis and outcomes. Despite this, the prognosis remains poor due to the high local recurrence rates and distant metastasis. 
Keywords
Carcinoma
Radiotherapy
Survival

Subjects

[1] Dasgupta T, Wilson LD, Yu JB. A retrospective review of 1349 cases of sebaceous carcinoma. Cancer. 2009;115(1):158-65. https://doi.org/10.1002/cncr.23952.
[2] Tripathi R, Chen Z, Li L, Bordeaux JS. Incidence and survival of sebaceous carcinoma in the United States. Journal of the American Academy of Dermatology. 2016;75(6):1210-5. https://doi.org/10.1016/j.jaad.2016.07.046.
[3] Sa HS, Rubin ML, Xu S, Ning J, Tetzlaff M, Sagiv O, et al. Prognostic factors for local recurrence, metastasis and survival for sebaceous carcinoma of the eyelid: observations in 100 patients. British Journal of Ophthalmology. 2019;103(7):980-4. https://doi.org/10.1136/bjophthalmol-2018-312635.
[4] Papadimitriou I, Vakirlis E, Sotiriou E, Bakirtzi K, Lallas A, Ioannides D. Sebaceous neoplasms. Diagnostics. 2023;13(10):1676. https://doi.org/10.3390/diagnostics13101676.
[5] Pleitz JL, Patel AB, Spires SE, Anderson FL, Aouad RK. A mass on the nasal dorsum. JAMA Otolaryngology–Head & Neck Surgery. 2014;140(3):267-8.
[6] Kyllo RL, Brady KL, Hurst EA. Sebaceous carcinoma: review of the literature. Dermatologic Surgery. 2015;41(1):1-15. https://doi.org/10.1097/DSS.0000000000000152.
[7] Cook S, Pethick J, Kibbi N, Hollestein L, Lavelle K, de Vere Hunt I, et al. Sebaceous carcinoma epidemiology, associated malignancies and Lynch/Muir-Torre syndrome screening in England from 2008 to 2018. Journal of the American Academy of Dermatology. 2023;89(6):1129-35. https://doi.org/10.1016/j.jaad.2023.03.046.
[8] Elston DM. Sebaceous neoplasms and the Muir-Torre syndrome. Journal of the American Academy of Dermatology. 2023;89(6):1123. https://doi.org/10.1016/j.jaad.2023.05.012.
[9] Hata M, Koike I, Omura M, Maegawa J, Ogino I, Inoue T. Noninvasive and curative radiation therapy for sebaceous carcinoma of the eyelid. International Journal of Radiation Oncology* Biology* Physics. 2012;82(2):605-11. https://doi.org/10.1016/j.ijrobp.2010.12.006.
International Journal of Scientific Research in Dental and Medical Sciences
Volume 6, Issue 2
Spring 2024
Pages 91-93

  • Receive Date 08 April 2024
  • Revise Date 11 May 2024
  • Accept Date 15 May 2024
  • Publish Date 24 May 2024