Evaluate Enhanced Bone Regeneration by Human Adult Dental Pulp Stem Cells Combination with Scaffold: A Systematic Review and Meta-analysis

Document Type : Review Article


1 Department of Prosthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran

2 Department of Operative Dentistry, Faculty of Dentistry, Islamic Azad University, Isfahan (Khorasgan) Branch, Isfahan, Iran

3 Faculty of Dentistry, Islamic Azad University, Isfahan (Khorasgan) Branch, Isfahan, Iran

4 Department of Periodontics, Faculty of Dentistry, Islamic Azad University, Isfahan (Khorasgan) Branch, Isfahan, Iran

5 Department of Periodontics, School of Dentistry, Centro Escolar University, Manila, Philippines

6 Endodontics Department, School of Dentistry, Islamic Azad University, Tehran, Iran


Background and aim: The present study has tried to provide evidence in this field by summarizing the results of animal studies because comprehensive results can lead to the decision of clinical trials in this field. Therefore, the present study was conducted to evaluate enhanced bone regeneration by human adult dental pulp stem cells combined with scaffold.
Material and methods: The present study was conducted based on PRISMA 2020-27-item checklist by giving the keywords stem cells, scaffold, bone regeneration and human dental pulp stem cells, all articles available in the international databases PubMed, Web of Science, Scopus, Science Direct, Web of Knowledge, EBSCO, Wiley, ISI, Elsevier, Embase databases and Google Scholar search engine were reviewed until November 2023. STATA/MP. v17 software was used in this meta-analysis. Meta-analysis was performed using mean differences with 95% confidence interval in meta-analysis.
Results: According to meta-analysis, the mean difference in bone regeneration between the experimental and control groups was 1.69 (MD:1.69; 95% CI 1.00 – 2.39, P<0.001). According to meta-analysis, a statistically significant difference was observed considering different groups of scaffolds on bone regeneration in combination with DPSC/SHED (MD:4.84; 95% CI 4.72– 4.95, P<0.001).
Conclusions: The present meta-analysis showed that dental pulp stem cells, along with scaffold, can increase new bone formation and accelerate bone formation compared to the control group.


Main Subjects

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