Primitive Neuroectodermal Tumor of Axilla: A Rare Case Report

Document Type : Case Reports


Department of Radiation Oncology, Regional Institute of Medical Sciences, Manipur University, Imphal, Manipur, India


Primitive neuroectodermal tumors (PNETs) are poorly differentiated small round cell neoplasms. It is commonly seen in children and is rare in adults. Superficial primitive neuroectodermal tumors are rare but have a favorable prognosis compared to conventional deep-seated tumors. PNETs are quite rare, with the incidence of PNET axilla being extremely rare, and very limited cases have been reported due to its rareness in literature. This paper reports a case of a 71-year-old male patient who presented with a right axillary swelling. He underwent wide local excision of axillary swelling, which on histopathological examination showed features consistent with primitive neuroectodermal tumor. He was treated with multimodality treatment. Further, treatment was deferred due to the poor general condition of the patient, and he was kept on the best supportive care.


Main Subjects

[1] Friedrichs N, Vorreuther R, Poremba C, Schafer KL, Böcking A, Buettner R, et al. Primitive neuroectodermal tumor (PNET) in the differential diagnosis of malignant kidney tumors. Pathology-Research and Practice. 2002;198(8):563-9.
[2] Tsokos M, Alaggio RD, Dehner LP, Dickman PS. Ewing sarcoma/peripheral primitive neuroectodermal tumor and related tumors. Pediatric and developmental pathology. 2012;15(1_suppl):108-26.
[3] Carvajal R, Meyers P. Ewing's sarcoma and primitive neuroectodermal family of tumors. Hematology/Oncology Clinics. 2005;19(3):501-25.
[4] Delaplace M, Lhommet C, De Pinieux G, Vergier B, De Muret A, Machet L. Primary cutaneous Ewing sarcoma: a systematic review focused on treatment and outcome. British Journal of Dermatology. 2012;166(4):721-6.
[5] Delattre O, Zucman J, Melot T, Garau XS, Zucker JM, Lenoir GM, et al. The Ewing family of tumors--a subgroup of small-round-cell tumors defined by specific chimeric transcripts. New England Journal of Medicine. 1994;331(5):294-9.
[6] Dehner LP. Primitive neuroectodermal tumor and Ewing's sarcoma. The American journal of surgical pathology. 1993;17(1):1-13.
[7] Folpe AL, Goldblum JR, Rubin BP, Shehata BM, Liu W, Dei Tos AP, et al. Morphologic and immunophenotypic diversity in Ewing family tumors: a study of 66 genetically confirmed cases. The American journal of surgical pathology. 2005;29(8):1025-33.
[8] Cheung CC, Kandel RA, Bell RS, Mathews RE, Ghazarian DM. Extraskeletal Ewing sarcoma in a 77-year-old woman. Archives of pathology & laboratory medicine. 2001;125(10):1358-60.
[9] Baldini EH, Demetri GD, Fletcher CD, Foran J, Marcus KC, Singer S. Adults with Ewing’s sarcoma/primitive neuroectodermal tumor: adverse effect of older age and primary extraosseous disease on outcome. Annals of surgery. 1999;230(1):79.
[10] Milanezi F, Pereira EM, Ferreira FV, Leitao D, Schmitt FC. CD99/MIC‐2 surface protein expression in breast carcinomas. Histopathology. 2001;39(6):578-83.
[11] Shravan S. Primitive Neuroectodermal Tumor of Axilla in an Adult: A Rare Entity. Journal of Clinical Case Studies Reviews & Reports. 2021;3(2):1-2.