Evaluation of the Effects of Nanoparticles in the Treatment of Diabetes Mellitus: A Systematic Review and Meta-analysis

Document Type : Review Article


1 Department of Pharmacology and Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Department of Cardiology, Rajayi Heart Center, Iran University of Medical Sciences, Tehran, Iran

3 Department of Internal Diseases, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

4 Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

5 Department of Internal Medicine, Noor Iranian Polyclinic, Muscat, Oman


Background and aim: Due to the importance of the issue in the treatment and prevention of diabetes mellitus, in the present study, it is decided to investigate the role of nanoparticles in the treatment or prevention of the development of diabetes mellitus. The aim of the present study was to evaluate the effects of nanoparticles in the treatment of diabetes mellitus.
Material and methods: The present study is a systematic review and meta-analysis based on PRISMA 2020 Checklist. Databases of PubMed, Scopus, Web of Science, EBSCO, ISI Web of knowledge, and Embase were searched for systematic literature until 20 November 2022. A 95% confidence interval for mean differences with the random effect model and REML method were calculated. Meta-analysis was performed using Stata/MP v.17 software.
Results: In the initial review, duplicate studies were eliminated, abstracts of 219 studies were reviewed, and two authors reviewed the full text of 184 studies. Finally, nine studies were selected. The mean differences in Fasting blood sugar between the silver nanoparticles group and zinc oxide nanoparticles vs. group was -209.92 (MD: -209.92 95% CI; -272.56, -147.28; p=0.00) and -1.58 (MD: -1.58 95% CI; -2.38, -0.78; p=0.00), respectively.
Conclusions: Based on the present meta-analysis, administering silver nanoparticles and zinc oxide nanoparticles in animal models can have antidiabetic effects and reduce fasting blood sugar levels.


Main Subjects

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Volume 4, Issue 4
December 2022
Pages 191-195
  • Receive Date: 25 September 2022
  • Revise Date: 29 November 2022
  • Accept Date: 05 December 2022
  • First Publish Date: 08 December 2022