Cytological Study of Salivary Gland Lesions along with Histopathological Correlation in a Tertiary Care Centre

Document Type : Original Article

Authors

Department of Pathology, Dr.D.Y.Patil Medical College, Hospital and Research Center, Pune, India

Abstract

Background and aim: This study aimed to analyze the relative frequency and distribution of different salivary gland lesions on Fine needle aspiration cytology, study histopathological correlation, and evaluate the accuracy and efficacy of this procedure in diagnosing the lesions.
Material and methods: A five-year study was performed on salivary gland swellings in a tertiary health care centre. Fine needle aspiration cytology was done, and smears were stained with Leishman, Haematoxylin, and eosin stains. Histopathology was done wherever possible. Cytological and histopathological correlation was done and the results were statistically analyzed.
Results: One hundred cases were studied. Lesions were categorized into non-neoplastic and neoplastic lesions. Chronic sialadenitis was the most common non-neoplastic lesion, and Pleomorphic Adenoma was the commonest benign lesion. Malignant lesions reported were Adenoid Cystic carcinoma, Mucoepidermoid carcinoma, Carcinoma ex pleomorphic adenoma, and three cases were interpreted as positive for malignancy.38 cases were available for histopathology, out of which 34 showed a positive correlation. The diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of the present study are 94.74%, 75%, 100%, 100%, and 100%, respectively.
Conclusions: Fine needle aspiration cytology is a rapid, cost-effective, and safe investigation for the primary categorization of salivary gland lesions into inflammatory, benign and malignant lesions. The high diagnostic accuracy and low false positive and false negative diagnosis suggest that it can be used as a first-line diagnostic procedure to evaluate patients with various salivary gland lesions. However, histopathological diagnosis remains the gold standard.

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References

[1]  Dey P. Diagnostic Cytology. Second Edition. Jaypee Brothers,Medical Publishers Pvt. Ltd. 2018.361-381.
[2]  Gore CR, Jadhav P, Jaiswal S, Chandanwale S, Kalkal P. Cytodiagnosis Of Salivary Gland Lesions. 2013;4(2):134-139.
[3]  Sharma M, Bala N, Angral S, Kapoor M, Goel M. FNAC of salivary gland lesions with histopathological and clinical correlation. Int J Oral Health Med Res. 2015;2:8-12.
[4]  Itagi IR. Evaluation of FNAC of head and neck swellings: a retrospective study. International Journal of Otorhinolaryngology and Head and Neck Surgery. 2018;4(1):189. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20175623.
[5]  Todase V, Panchonia A, Kulkarni CV, Mehar R, Shinde P, Likhar K, et al. Cytopathological study of salivary gland lesion in patients at a tertiary care centre, Indore: a one-year study. Int J Res Med Sci. 2017;5(6):2406-11.
[6]  Sandhu VK, Sharma U, Singh N, Puri A. Cytological spectrum of salivary gland lesions and their correlation with epidemiological parameters. Journal of oral and maxillofacial pathology: JOMFP. 2017;21(2):203-10. https://doi.org/10.4103%2Fjomfp.JOMFP_61_17.
[7]  Yogambal M, Chandramouleeswari K, Marylilly SA. Role of fine needle aspiration cytology in salivary gland pathology and its histopathological correlation: a five year descriptive study in a tertiary care centre. Online Journal of Otolaryngology. 2015;5(4):54.
[8]  Tessy PJ, Jayalekshmy PS, Cicy PJ, Poothiode U. Fine needle aspiration cytology of salivary gland lesions with histopathological correlation–A two year study. Int J Healthc Biomed Res. 2015;3(4):91-9.
[9]  Poudel A, Shrestha B, Regmi S. Evaluation of Salivary Gland Lesions by Fine Needle Aspiration Cytology at a Tertiary Care Hospital, Western Nepal. Pathology and Laboratory Medicine International. 2020;12:9-17. https://doi.org/10.2147/PLMI.S266866.
[10] Kambale T, Iqbal B, Patil A, Kumar H. Diagnostic role of FNAC in salivary gland lesions and its histopathological correlation. Indian Journal of Pathology and Oncology. 2016;3(3):372-5. https://doi.org/10.5958/2394-6792.2016.00070.3.
[11] Krishnamurthy S, Vasudeva SB, Vijayasarathy S. Salivary gland disorders: A comprehensive review. World Journal of Stomatology. 2015;4(2):56-71. http://dx.doi.org/10.5321/wjs.v4.i2.56.
[12] Gupta S, Dayal S, Pandey P, Krishna M, Maurya G, Singh SK, et al. FNAC is a Boon for Salivary Gland Lesions: A Routine Diagnostic Experience among Rural Population. Journal of Clinical & Diagnostic Research. 2019;13(4):8-11.
[13] Sikdar N, Sriram V, Ivan EA. Cytological and histopathological correlation of salivary gland lesions. JMSRC. 2018;6:127-39. https://dx.doi.org/10.18535/jmscr/v6i7.21.
[14] Koirala S, Sayami G, Pant AD. Correlation of FNAC and histopathology in diagnosis of salivary gland lesions. Journal of Pathology of Nepal. 2014;4(8):654-7.
[15] AlGhamdi GZ, Alzahrani AK, Saati H, Algarni HM, Alshehri KA, Baroom M, et al. Correlation between fine needle aspiration cytology (FNAC) and permanent histopathology results in salivary gland masses. Cureus. 2021;13(3): e13976. https://doi.org/10.7759/cureus.13976.
[16] Singh G, Jahan A, Yadav SK, Gupta R, Sarin N, Singh S. The Milan System for Reporting Salivary Gland Cytopathology: an outcome of retrospective application to three years’ cytology data of a tertiary care hospital. Cytojournal. 2021;18. https://doi.org/10.25259%2FCytojournal_1_2021.
International Journal of Scientific Research in Dental and Medical Sciences
Volume 4, Issue 3
September 2022
Pages 101-109

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History

  • Receive Date: 21 June 2022
  • Revise Date: 03 August 2022
  • Accept Date: 14 August 2022

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