Analysis of Intraocular Pressure Variation with Use of Steroid Eye Drops as Post-operative Medication in Cataract Patients

Document Type : Original Article


Department of Ophthalmology, Muzaffarnagar Medical College, Chaudhary Charan Singh University, Meerut, India


Background and aim: Steroid drops are necessarily used after cataract surgery to control the ocular inflammation, but they can increase the intraocular pressure. Using two different steroid eye drops as post-operative medication after cataract surgery to compare the intraocular pressure variation and control of ocular inflammation.
Material and methods: A comparative hospital-based study was conducted on 180 patients who underwent cataract surgery with Intraocular lens implantation. Two groups 1 and 2 were made based on the exposure to either Dexamethasone 0.1% e/d or Prednisolone acetate 1% e/d, respectively. Both drops were prescribed six times daily for the first week and gradually tapered off in 6 weeks. The anti-inflammatory effect and mean IOP rise from baseline in groups 1 and 2 were analyzed and compared. Statistical analysis was done using SPSS 24.0.
Results: Intraocular Pressure increase was noted more in group 1 (25.56%) versus group 2 (17.78%), with a statistically significant difference (p<0.05) after one week. after the fourth and sixth weeks, the intraocular pressure rise (IOP) was observed in 15.56% and 8.89% versus 10% and 4.44% of the subjects in Group 1 and group 2, respectively. Both the drugs effectively controlled ocular inflammation, and there was no significant difference in their anti-inflammatory effects.
Conclusions: Our study concludes that dexamethasone is equally efficacious to Prednisolone in managing post-cataract ocular inflammation with marginally raised IOP in the first week in steroid responders. IOP returns to baseline with a reduction of the drop's frequency.


Main Subjects

[1] World Health Organization (WHO). Informal consultation on analysis of blindness prevention outcomes. Geneva. WHO. WHO/PBL/98/68.
[2] Rugstad HE. Antiinflammatory and immunoregulatory effects of glucocorticoids: mode of action. Scandinavian Journal of Rheumatology. 1988;17(sup76):257-64.
[3] Francois J. Cortisone et tension ocularire. Ann Ocul. 1954;187:805-16.
[4] Donnenfeld ED, Holland EJ, Solomon KD, Fiore J, Gobbo A, Prince J, et al. A multicenter randomized controlled fellow eye trial of pulse-dosed difluprednate 0.05% versus prednisolone acetate 1% in cataract surgery. American journal of ophthalmology. 2011;152(4):609-17.
How to Cite this Article: Malhotra S, Shukla P, Mithal K, Bhartiya S, Singh VP, Dhamejani MD. Analysis of Intraocular Pressure Variation with Use of Steroid Eye Drops as Post-operative Medication in Cataract Patients. International Journal of Scientific Research in Dental and Medical Sciences. 2022;4(2):67-72.
[5] Carnahan MC, Goldstein DA. Ocular complications of topical, peri-ocular, and systemic corticosteroids. Current opinion in ophthalmology. 2000;11(6):478-83.
[6] Phulke S, Kaushik S, Kaur S, Pandav SS. Steroid-induced glaucoma: an avoidable irreversible blindness. Journal of current glaucoma practice. 2017;11(2):67-72.
[7] Razeghinejad MR, Katz LJ. Steroid-induced iatrogenic glaucoma. Ophthalmic research. 2012;47(2):66-80.
[8] Becker B, MILLS DW. Corticosteroids and intraocular pressure. Archives of ophthalmology. 1963;70(4):500-7.
[9] Armaly MF. Effect of corticosteroids on intraocular pressure and fluid dynamics: I. The effect of dexamethasone* in the normal eye. Archives of ophthalmology. 1963;70(4):482-91.
[10] Kersey JP, Broadway DC. Corticosteroid-induced glaucoma: a review of the literature. Eye. 2006;20(4):407-16.
[11] Quigley HA, Sanchez RM, Dunkelberger GR, L'Hernault NL, Baginski TA. Chronic glaucoma selectively damages large optic nerve fibers. Investigative Ophthalmology & Visual Science. 1987;28(6):913-20.
[12] Smith S, Lorenz D, Peace J, McLeod K, Crockett RS, Vogel R. Difluprednate ophthalmic emulsion 0.05%(Durezol®) administered two times daily for managing ocular inflammation and pain following cataract surgery. Clinical Ophthalmology (Auckland, NZ). 2010;4:983-91.
[13] Babu M, Abhilash B. Comparative analysis of the post-operative anti-inflammatory effect of topical 0.1% Dexamethasone sodium eye drops, topical 1% Prednisolone acetate eye drops and difluprednate 0.05% topical eye drops after small incision cataract surgery at a tertiary eye care institute in India. IP Int J Ocul Oncology Oculoplasty 2021;7(1):71-76.
[14] Mohan K, Lune AA, Goud R, Desai CC, Cardoza NJ. Study of prevalence of raised IOP in post cataract patients following topical steroid usage. Indian Journal of Clinical and Experimental Ophthalmology. 2021;7(2):436-41.
[15] Prasad D, Lokesh HM. A Clinical Study on Changes in Iop after Dexamethasone Usage Following Manual Small Incision Cataract Surgery. Journal of Medical Science And clinical Research. 2021;9(1):195-200.
[16] Armaly MF. Inheritance of dexamethasone hypertension and glaucoma. Archives of Ophthalmology. 1967;77(6):747-51.
[17] Becker B. Intraocular pressure response to topical corticosteroids. Investigative Ophthalmology & Visual Science. 1965;4(2):198-205.
[18] Mohan H, Alias Devasena MM. Effects of Steroid Eye Drops on Intraocular Pressure in Post Operative Cataract Patients in a Tertiary Center. Indian Journal of Public Health Research & Development. 2019;10(9):118-22.
[19] Mathew KM, Thomas LK, Stanly M, Scaria M, Philip A, Anandkumar S. Comparison of three different eye drops and assessment of IOP changes in post-operative cataract patients. International Journal of Medicine Research. 2018;3(4):31–3.
[20] Malik A, Sadafale A, Gupta YK, Gupta A. A comparative study of various topical nonsteroidal anti-inflammatory drugs to steroid drops for control of post cataract surgery inflammation. Oman journal of ophthalmology. 2016;9(3):150-6.