Assessing the Effects of L-PRF on the Peri-implant Soft and Hard Tissue Parameters in Immediate Implants: A Randomised Controlled Trial

Document Type : Original Article

Authors

1 Department of Periodontology and Implantology, BRS Dental College and Hospital, Panchkula, Haryana, India

2 Doctor of Dental Surgery, Jammu, India

Abstract

Background and aim: Platelet-rich fibrin is a healing biomaterial with greater potential for enhancing tissue and osseous healing and regeneration without inflammatory reactions and can be used alone or in combination with bone grafts to promote blood coagulation bone maturation and growth. Although the use of platelet-rich plasma in dentistry, enhancing peri-implant healing with immediate implants placement is not well authenticated. The main aim of this study is to assess the effect of Leukocyte-and Platelet-Rich Fibrin (L-PRF) on the peri-implant soft and hard tissue parameters in immediate implants.
Materials and methods: The split-mouth, randomized controlled trial on 10 systematically healthy subjects with adequate and maintainable oral hygiene. Subjects were enrolled, and sites were specified. On one site, atraumatic extraction was followed by immediate implant placement, while at another site, atraumatic extraction was done, followed by immediate implant placement with L-PRF application. Patients were recalled after 1, 3, and 6 months to evaluate various parameters, including tissue biotype, whether thick or thin, radiographic radiolucency (present or absent), modified plaque index, modified sulcus bleeding index, probing depth. The data was compiled and evaluated with an ANOVA test with a significant p-value of 0.05.
Results: Statistically significant values were observed in all the parameters evaluated after the surgical procedure at 1, 3, and 6-month intervals with immediate implant placement along with Leukocyte-and Platelet-Rich Fibrin (L-PRF) membrane in extraction sockets.
Conclusion: Within the study's limitation, it can be concluded that L-PRF can be used as a therapeutic adjuvant in clinical conditions of one-stage single tooth implant placements.

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[1]  Ragab O, Shoeib MA, El Nahass H.  A comparative study of the effect of leukocytes and platelets-rich fibrin on the stability of immediate implants using early loading protocol. Cario dental journal. 2013;29(2):1-8.
[2]  Chen CL, Chang CL, Lin SJ. Immediate implant placement and provisionalization with simultaneous guided bone regeneration in the esthetic zone. Journal of Dental Sciences. 2011;6(1):53-60. https://doi.org/10.1016/j.jds.2011.01.001.
[3]  Diana C, Mohanty S, Chaudhary Z, Kumari S, Dabas J, Bodh R. Does platelet-rich fibrin have a role in osseointegration of immediate implants? A randomized, single-blind, controlled clinical trial. International journal of oral and maxillofacial surgery. 2018;47(9):1178-88. https://doi.org/10.1016/j.ijom.2018.01.001.
[4]  Preeja C, Arun S. Platelet-rich fibrin: Its role in periodontal regeneration. The Saudi Journal for Dental Research. 2014;5(2):117-22. https://doi.org/10.1016/j.ksujds.2013.09.001.
[5]  Boora P, Rathee M, Bhoria M. Effect of platelet rich fibrin (PRF) on peri-implant soft tissue and crestal bone in one-stage implant placement: a randomized controlled trial. Journal of clinical and diagnostic research: JCDR. 2015;9(4):ZC18. doi: 10.7860/JCDR/2015/12636.5788.
[6]  Del Corso M, Dohan Ehrenfest DM. Immediate implantation and peri-implant Natural Bone Regeneration (NBR) in the severely resorbed posterior mandible using Leukocyte-and Platelet-Rich Fibrin (L-PRF): a 4-year follow-up. Poseido. 2013;1(2):109-116.
[7]  Isler SC, Uraz A, Kaymaz O, Cetiner D. An evaluation of the relationship between peri-implant soft tissue biotype and the severity of peri-implantitis: a cross-sectional study. Int J Oral Maxillofac Implants. 2019;34(1):187-96.
[8]  Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2006;101(3):e45-50. https://doi.org/10.1016/j.tripleo.2005.07.009.
[9]  Meltzer AM. Primary stability and initial bone-to-implant contact: The effects on immediate placement and restoration of dental implants. J Implant Reconstr Dent. 2009;1(1):35-41.
[10] Wilson Jr TG, Schenk R, Buser D, Cochran D. Implants placed in immediate extraction sites: a report of histologic and histometric analyses of human biopsies. International Journal of Oral & Maxillofacial Implants. 1998;13(3):333-341.
[11] Tarnow DP, Chu SJ. Human histologic verification of osseointegration of an immediate implant placed into a fresh extraction socket with excessive gap distance without primary flap closure, graft, or membrane: a case report. International Journal of Periodontics & Restorative Dentistry. 2011;31(5):515-521.
[12] Simonpieri A, Del Corso M, Sammartino G, Ehrenfest DM. The relevance of Choukroun’s platelet-rich fibrin and metronidazole during complex maxillary rehabilitations using bone allograft. Part I: a new grafting protocol. Implant dentistry. 2009;18(2):102-11. doi: 10.1097/ID.0b013e318198cf00.
[13] Naik B, Karunakar P, Jayadev M, Marshal VR. Role of Platelet rich fibrin in wound healing: A critical review. Journal of conservative dentistry: JCD. 2013;16(4):284-293. doi: 10.4103/0972-0707.114344.