Epidermoid Cyst in an Unusual Location: A Case Report

Document Type : Case Reports


Department of Oral Surgery, School of Dentistry, Universidad del Zulia, Venezuela


Epidermoid cysts account for approximately 80% of follicular skin cysts. They are considered a benign condition that can occur anywhere in the body; in the microscopic examination, this cyst reveals a cavity lined by stratified squamous epithelium resembling an epidermis, a lumen filled with degenerating orthokeratin. It is sporadic in the oral cavity, representing only 1.6% of all cysts. Its appearance in the buccal mucosa has been poorly reported. The purpose of this article is to describe a case of a 22-year-old male with an epidermoid cyst in this unusual location. This entity should not be ruled out of lesions that may occur in the oral cavity, even when its incidence is extremely low.


Main Subjects

[1] Sahoo NK,  Choudhary AK, Srinivas V, Tomar K. Dermoid cysts of maxillofacial region. Med J Armed Forces India. 2015; 71(2):S389–S394. DOI: http://dx.doi.org/10.1016/j.mjafi.2013.11.004.
[2] Trung V, Thao C, Hung C, Chansomphoud V, Chansomphoue V, Tinh T. Overview of epidermoid cyst. Eur J Radiol Open. 2019;(6):291–301. DOI: https://doi.org/10.1016/j.ejro.2019.08.003.
[3] Neville B, Damm D, Allen C, Chi A. Oral and maxillofacial pathology: 4th ed. United States. Elsevier. 2016. Pp-32-34.
[4] Sakamoto Y, Baba T, Kouzu Y, Koike H, Kasamatsu A, Ogawara K et al. A case of an epidermoid cyst arising in the maxillary sinus. J Oral Maxillofac Surg Med Pathol. 2014;(26):228–231. DOI: http://dx.doi.org/10.1016/j.ajoms.2012.05.017.
[5] Zito PM, Scharf R. Cyst, Epidermoid (Sebaceous Cyst). [Internet]. United States. StatPearls Publishing. Updated 2019 Dec 25 [Rev. 2020 april]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK499974/.
[6] Pires-Gonçalves L, Silva C, Teixeira M, Costa-Dias S, Sousa-Mendes V. Testicular epidermoid cyst - Ultrasound and MR typical findings with macroscopy correlation. International Braz J Urol. 2011;37(4):534-535. DOI: https://doi.org/10.1590/s1677-55382011000400014.
[7] Janarthanam J, Mahadevan S. Epidermoid cyst of submandibular region. J Oral Maxillofac Pathol. 2012; 16(3):435–437. DOI: https://doi.org/10.4103/0973-029x.102511.
[8] Tanaka E, Matsuokab Y, Hamaguchic M, Yamamotod Y, Yonemitsue K. Large epidermoid cyst in lateral floor of mouth and submandibular region. Asian Journal of Oral and Maxillofacial Surgery. 2011; 23(2):99-101. DOI: 10.1016/j.ajoms.2011.01.004.
[9] Zeeshan Q, Kashif I, Tayyaba F. Sublingual epidermoid cyst mimicking as plunging ranula – A case report. Int J Dent Sci Res. 2016; 3(1):22-25. DOI: http://dx.doi.org/10.1016/j.ijdsr.2015.11.004.
[10] Koca H, Seckin T, Sipahi A, Kazanc A. Epidermoid cyst in the floor of the mouth: report of a case. Quintessence Int. 2007;38:473-7.
[11] Turetschek K, Hospodka H, Steiner E. Case report: epidermoid cyst of the floor of the mouth: diagnostic imaging by sonography, computed tomography and magnetic resonance imaging. Br J Radiol. 1995;68:205-7. DOI: 10.1259/0007-1285-68-806-205.
[12] Jham B, Duraes G, Jham A, Santos C. Epidermoid Cyst of the Floor of the Mouth: A Case Report. Clinical Practice. 2007; 73(6):525-528.
[13] Da Silveira H, Lopes M, Yamamoto L, Ribeiro L, Prado K, Dias J, Esquiche J. Intraoral Epidermoid Cyst With Extensive Elastofibromatous Changes: An Extremely Rare Finding. OOOO. 2020;129(1):e53-e54. DOI: https://doi.org/10.1016/j.oooo.2019.06.194.
[14] Papanayotou PH, Kayavis JG. Epidermoid implantation cyst of the lower lip: report of case. J Oral Surg. 1977 Jul;35(7):585-6.
[15] Phukan JP, Sinha A, Pal S, Jalan S. Cytodiagnosis of epidermoid cyst of the upperlip; A common lesion in an uncommon site. J Lab Physicians. 2014 Jan;6(1):60-2. DOI: 10.4103/0974-2727.129097.
[16] Kuroyanagi K, Kawabata T, Tooi M. Epidermoic cyst of upper lip: report of a case. Bull Tokyo dent coll.1973 May;14(2):95-8.
[17] Maranhão C, Freire P, Botelho T. Atypical appearance of epidermoid cyst in tongue’s ventral surface. RSBO. 2011 Apr-Jun;8(2):240-2.
[18] Gurgel F, Rodrigues F, Nobre F, Almeida S, Negreiros A, Socorro R, Sousa F et al. Epidermoid Cyst Arising in the Buccal Mucosa: Case Report and Literature Review. Acta Stomatol Croat. 2015; 49(1):65–73. DOI: 10.15644/asc48/4/8.
[19] Ozan F, Polat HB, Ay S, Goze F. Epidermoid Cyst of the Buccal Mucosa: A Case Report. J Contemp Dent Pract. 2007;8(3):90-6.
[20] Costa P, Arantes E, Campos T, Grillo M, Roma M, Benevenuto B. et al. Epidermoid Cyst Of The Buccal Region Of The Face. OOOO. 2020; 129(1):e101. DOI: https://doi.org/10.1016/j.oooo.2019.06.429.
[21] Denison C, Ward V, Lester S, DiPiro P, Smith D, Meyer J. et al. Epidermal inclusion cysts of the breast: three lesions with calcifications. Radiology 1997;204(2): 493–496. DOI: 10.1148/radiology.204.2.9240542.
[22] Dutta M, Saha J, Biswas G, Sen I, Sinha R. Epidermoid cysts in head and neck: our experiences, with review of literature. Indian J. Otolaryngol. Head Neck Surg. 2013; (65):14–21. DOI: 10.1007/s12070-011-0363-y.
[23] Nakamura T. Comparative immunohistochemical analyses on the modes of cell death/keratinization in epidermal cyst, trichilemmal cyst, and pilomatricoma. Am J Dermatopathol. 2011 Feb;33(1):78-83. DOI: 10.1097/DAD.0b013e3181e3aec1.
[24] Terada T. Squamous cell carcinoma originated from an epidermal cyst. Int J Clin Exp Pathol. 2012;5(5):479-81. 
[25] Caly D, Viana A, Rapoport A, Dedivitis R, Curioni O, Cernea C, Brandão L. Indications and pitfalls of immunohistochemistry in head and neck cancer. Braz J Otorhinolaryngol. 2013;79(1):75-81. DOI: 10.5935/1808-8694.20130013.
[26] Bin Manie M, Al-Qahtani K, Al Ammar A, Islam T, Otaibi F. Epidermoid cyst of the suprasternal region: a rare case report. Braz. J. Otorhinolaryngol. 2020; 86(1): 133-135. DOI: 10.1016/j.bjorl.2016.04.010.
[27] Sempowski I. Sebaceous cysts. Ten tips for easier excision. Can Fam Physician. 2006;52(3):315–317.