Is Low-Level Laser Therapy Effective for Complications of Mandibular Third Molar Surgery? A Literature Review

Document Type : Review Article


1 Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Guilan University of Medical Sciences, Rasht, Iran

2 Student Research Committee, Faculty of Dentistry, Guilan University of Medical Sciences, Rasht, Iran


Background and aim: Wisdom tooth surgery, as one of the most routine surgeries, has various complications and difficulties for which there is no comprehensive remedy that can compromise all the side effects.
Materials and methods: Low-level laser therapy is a recently recommended method with inconsistent results in different studies done past few decades, but it can be the treatment of choice. By a strategic search of keywords in PUBMED, MEDLINE, and GOOGLE SCHOLAR, 72 articles were explored.
Results: Seventeen randomized clinical trials and preliminary articles were selected based on inclusion and exclusion criteria, such as the coordination of articles with the concept, full-text availability, and clinical trials. (application of laser in fields other than surgery is an exclusion criterion) The data were sorted as four tables after perusal of all the pick-up papers.
Conclusion: Through different sketching of studies and laser applications used, other outcomes are justifiable and reasonable.


Main Subjects

[1]  Alan H, Yolcu Ü, Koparal M, Özgür C, Öztürk SA, Malkoç S. Evaluation of the effects of the low-level laser therapy on swelling, pain, and trismus after removal of impacted lower third molar. Head & face medicine. 2016;12(1):25.10.1186/s13005-016-0121-1.
[2]  Leung YY, Fung PP, Cheung LK. Treatment modalities of neurosensory deficit after lower third molar surgery: a systematic review. Journal of Oral and Maxillofacial Surgery. 2012;70(4):768-78.10.1016/j.joms.2011.08.032.
[3]  Pol R, Ruggiero T, Gallesio G, Riso M, Bergamasco L, Mortellaro C, Mozzati M. Efficacy of anti-inflammatory and analgesic of superpulsed low level laser therapy after impacted mandibular third molars extractions. Journal of Craniofacial Surgery. 2016;27(3):685-90.1097/SCS.0000000000002523.
[4]  Landucci A, Wosny AC, Uetanabaro LC, Moro A, Araujo MR. Efficacy of a single dose of low-level laser therapy in reducing pain, swelling, and trismus following third molar extraction surgery. International journal of oral and maxillofacial surgery. 2016;45(3):392-8.
[5]  Markovic A, Todorovic LJ. Effectiveness of dexamethasone and low-power laser in minimizing oedema after third molar surgery: a clinical trial. International journal of oral and maxillofacial surgery. 2007;36(3):226-9.10.1016/j.ijom.2006.10.006.
[6]  Sierra SO, Deana AM, Ferrari RA, Albarello PM, Bussadori SK, Fernandes KP. Effect of low-level laser therapy on the post-surgical inflammatory process after third molar removal: study protocol for a double-blind randomized controlled trial. Trials. 2013;14(1):1-7.10.1186/1745-6215-14-373.
[7]  Aras MH, Güngörmüş M. The effect of low-level laser therapy on trismus and facial swelling following surgical extraction of a lower third molar. Photomedicine and laser surgery. 2009;27(1):21-4. 10.1089/pho.2008.2258.
[8]  Brignardello-Petersen R, Carrasco-Labra A, Araya I, Yanine N, Beyene J, Shah PS. Is adjuvant laser therapy effective for preventing pain, swelling, and trismus after surgical removal of impacted mandibular third molars? A systematic review and meta-analysis. Journal of oral and maxillofacial surgery. 2012;70(8):1789-801.10.1016/j.joms.2012.01.008.
[9]  He WL, Yu FY, Li CJ, Pan J, Zhuang R, Duan PJ. A systematic review and meta-analysis on the efficacy of low-level laser therapy in the management of complication after mandibular third molar surgery. Lasers in medical science. 2015;30(6):1779-88.10.1007/s10103-014-1634-0.
[10] Batinjan G, Zore Z, Čelebić A, Papić M, Pandurić DG, Zore IF. Thermographic monitoring of wound healing and oral health-related quality of life in patients treated with laser (aPDT) after impacted mandibular third molar removal. International journal of oral and maxillofacial surgery. 2014;43(12):1503-8.10.1016/j.ijom.2014.09.003.
[11] Kathuria V, Dhillon JK, Kalra G. Low level laser therapy: a panacea for oral maladies. Laser therapy. 2015;24(3):215-23. 10.5978/islsm.15-RA-01.
[12] Merigo E, Clini F, Fornaini C, Oppici A, Paties C, Zangrandi A, Fontana M, Rocca JP, Meleti M, Manfredi M, Cella L. Laser-assisted surgery with different wavelengths: a preliminary ex vivo study on thermal increase and histological evaluation. Lasers in medical science. 2013;28(2):497-504.10.1007/s10103-012-1081-8.
[13] Khalighi HR, Anbari F, Taheri JB, Bakhtiari S, Namazi Z, Pouralibaba F. Effect of low-power laser on treatment of orofacial pain. Journal of Dental Research, Dental Clinics, Dental Prospects. 2010;4(3):75. 10.5681/joddd.2010.019.
[14] Roynesdal AK, Björnland T, Barkvoll P, Haanaes HR. The effect of soft-laser application on postoperative pain and swelling: a double-blind, crossover study. International journal of oral and maxillofacial surgery. 1993;22(4):242-5.10.1016/s0901-5027(05)80646-0.
[15] López-Ramírez M, Vílchez-Pérez MÁ, Gargallo-Albiol J, Arnabat-Domínguez J, Gay-Escoda C. Efficacy of low-level laser therapy in the management of pain, facial swelling, and postoperative trismus after a lower third molar extraction. A preliminary study. Lasers in medical science. 2012;27(3):559-66.10.1007/s10103-011-0936-8.
[16] Bjordal JM, Johnson MI, Iversen V, Aimbire F, Lopes-Martins RA. Low-level laser therapy in acute pain: a systematic review of possible mechanisms of action and clinical effects in randomized placebo-controlled trials. Photomedicine and Laser Therapy. 2006;24(2):158-68.10.1089/pho.2006.24.158.
[17] Fernando S, Hill CM, Walker R. A randomised double blind comparative study of low level laser therapy following surgical extraction of lower third molar teeth. British Journal of Oral and Maxillofacial Surgery. 1993;31(3):170-2.10.1016/0266-4356(93)90118-g.
[18] Ferrante M, Petrini M, Trentini P, Perfetti G, Spoto G. Effect of low-level laser therapy after extraction of impacted lower third molars. Lasers in medical science. 2013;28(3):845-9.10.1007/s10103-012-1174-4.
[19] Aras MH, Güngörmüş M. Placebo-controlled randomized clinical trial of the effect two different low-level laser therapies (LLLT)—intraoral and extraoral—on trismus and facial swelling following surgical extraction of the lower third molar. Lasers in medical science.2010;25(5):641-5.10.1007/s10103-009-0684-1.
[20] Fabre HS, Navarro RL, Oltramari-Navarro PV, Oliveira RF, Pires-Oliveira DA, Andraus RA, Fuirini N, Fernandes KB. Anti-inflammatory and analgesic effects of low-level laser therapy on the postoperative healing process. Journal of physical therapy science. 2015;27(6):1645-8. 10.1589/jpts.27.1645.
 [21] Koparal M, Ozcan Kucuk A, Alan H, Asutay F, Avci M. Effects of low-level laser therapy following surgical extraction of the lower third molar with objective measurement of swelling using a three-dimensional system. Experimental and therapeutic medicine. 2018;15(4):3820-6.10.3892/etm.2018.5921.
[22] Raiesian S, Khani M, Khiabani K, Hemmati E, Pouretezad M. Assessment of low-level laser therapy effects after extraction of impacted lower third molar surgery. Journal of Lasers in Medical Sciences. 2017;8(1):42. 10.15171/jlms.2017.08.
[23] Sampaio-Filho H, Sotto-Ramos J, Pinto EH, Cabral MR, Longo PL, Tortamano IP, Marcos RL, Silva DF, Pavani C, Horliana AC. Evaluation of low-level laser at auriculotherapy points to reduce postoperative pain in inferior third molar surgery: study protocol for a randomized controlled trial. Trials. 2016;17(1):1-9. 10.1186/s13063-016-1540-9.
[24] Schultze-Mosgau S, Schmelzeisen R, Frölich JC, Schmele H. Use of ibuprofen and methylprednisolone for the prevention of pain and swelling after removal of impacted third molars. Journal of Oral and Maxillofacial Surgery. 1995;53(1):2-7. 10.1016/0278-2391(95)90486-7.
Volume 2, Issue 3
September 2020
Pages 72-80
  • Receive Date: 29 April 2020
  • Revise Date: 02 June 2020
  • Accept Date: 26 June 2020
  • First Publish Date: 01 September 2020