It is widely accepting that Myiasis refers to an infestation of alive human animals or vertebrates from larvae of the Diptera insect family that feed on live or necrotic tissues depending on the species. The Cochliomyia hominivorax species is the most common, which feeds entirely on the necrotic tissues and is commonly founding in tropical and subtropical areas, first screw-worm larvae fed on the living tissues so that the egg deposition occurs on the periphery of the new wounds. The most common locations in the head and neck where this infestation appears are the ears, eyes, nose, oral cavity, sinuses, mastoid region, tracheotomy wound, and lymph nodes. Multiple parameters predispose to the possibility of presenting Myiasis in this area, such as the increased age, lower socioeconomic status as well as medical co-morbidities, and malignant tumors. Therefore, this study presented a case of a 71-year old patient with orofacial Myiasis, who received medical treatment, mechanical removal, surgical debridement and occlusion of the wound with liquor based on the essence of anis or anisette for the asphyxia of the larvae, with a satisfactory evolution after seven days of the protocol. This case provides interesting information that could help oral and maxillofacial surgeons manage the type of orofacial Myiasis