Hybrid Odontogenic Tumor with a unique presentation of the Calcifying Epithelial Odontogenic Tumor, Adenomatoid Odontogenic Tumor, and Calcifying Odontogenic Cyst: A Case Report

Document Type : Case Reports

Authors

1 Department of Oral and Maxillofacial Surgery, School of Dentistry, University Hospital of Maracaibo, Zulia, Venezuela

2 Department of Oral and Maxillofacial Pathology, School of Dentistry, Emory University, USA

3 Department of Oral and Maxillofacial Surgery, School of Dentistry, La Universidad del Zulia, Venezuela

Abstract

There are rarely hybrid neoplasms composed of two or more distinct histological types; a hybrid odontogenic tumor with a combination of the calcifying epithelial odontogenic tumor (CEOT) is present, adenomatoid odontogenic tumor (AOT) and calcifying odontogenic cyst (COC), located in the anterior mandible region from a 15-year-old male patient causing mild mobility of anterior mandible incisors with the labial and lingual expansion of the mandible cortical plates and obvious facial asymmetry. The tumor was surgically removed through an en-bloc resection approach. Microscopic examination revealed an atypical hybrid odontogenic tumor, with features of the three entities previously mentioned. Several cases of hybrid neoplasms have been reported in the literature. However, there is no evidence about the incidence of a hybrid odontogenic tumor with histologic features of CEOT combined with two other entities. In combination with COC, this is a unique presentation of a hybrid tumor not previously documented.

Keywords

Main Subjects


[1] Yamazaki M, Maruyama S, Abé T, Babkair H, Fujita H, Takagi R, et al. Hybrid ameloblastoma and adenomatoid odontogenic tumor: report of a case and review of hybrid variations in the literature. Oral surgery, oral medicine, oral pathology and oral radiology. 2014;118(1):e12-8. https://doi.org/10.1016/j.oooo.2013.08.032.
[2] Phillips MD, Closmann JJ, Baus MR, Torske KR, Williams SB. Hybrid odontogenic tumor with features of ameloblastic fibro-odontoma, calcifying odontogenic cyst, and adenomatoid odontogenic tumor: a case report and review of the literature. Journal of oral and maxillofacial surgery. 2010;68(2):470-4. DOI:https://doi.org/10.1016/j.joms.2009.04.118.
[3] Wright JM, Vered M. Update from the 4th edition of the World Health  
      Organization classification of head and neck tumours: odontogenic and  
      maxillofacial bone tumors. Head and neck pathology. 2017;11(1):68-77.  
      https://doi.org/10.1007/s12105-017-0794-1.
 [4] AB RS, Ogle OE. Odontogenic Tumors. Dental Clinics of North America. 2019;64(1):121-38. DOI: 10.1016/j.cden.2019.08.008.
[5] Ibituruna AC, Costa AR, de Paulo LF, de Faria PR, Cardoso SV, Loyola AM. Multiple calcifying epithelial odontogenic tumor: case report and review of the literature. Oral surgery, oral medicine, oral pathology and oral radiology. 2019;128(3):268-72. https://doi.org/10.1016/j.oooo.2019.03.018.
[6] Bilodeau EA, Seethala RR. Update on odontogenic tumors: proceedings of the North American Head and Neck Pathology Society. Head and neck pathology. 2019;13(3):457-65. https://doi.org/10.1007/s12105-019-01013-5.
[7] Seim P, Regezi JA, O’Ryan F. Hybrid ameloblastoma and calcifying epithelial odontogenic tumor: case report. Journal of oral and maxillofacial surgery. 2005;63(6):852-5. DOI:https://doi.org/10.1016/j.joms.2005.02.024.
[8] Etit D, Uyaroglu MA, Erdogan N. Mixed odontogenic tumor: Ameloblastoma and calcifying epithelial odontogenic tumor. Indian Journal of Pathology and Microbiology. 2010;53(1):122-124. DOI: 10.4103/0377-4929.59201.
[9] Martin-Duverneuil N, Roisin-Chausson MH, Behin A, Favre-Dauvergne E, Chiras J. Combined benign odontogenic tumors: CT and MR findings and histomorphologic evaluation. American journal of neuroradiology. 2001;22(5):867-72.
[10] Wadhwan V, Sharma P, Bansal V. A rare case of hybrid odontogenic tumor: Calcifying epithelial odontogenic tumor combined with ameloblastoma. Journal of oral and maxillofacial pathology: JOMFP. 2015;19(2):268. doi: 10.4103/0973-029X.164560.
[11] Rathod V, Saluja S, Gondhalekar R, Pundir S, Dixit S, Agrawal S. Hybrid odontogenic lesion of the mandible: a rare case report with literature review. International Journal of Oral-Medical Sciences. 2014;12(4):245-50. https://doi.org/10.5466/ijoms.12.245.
[12] Rosa AC, Soares AB, Furuse C, Lima SR, de Araújo VC, Passador-Santos F. A combined epithelial odontogenic tumor? A 7-year follow-up case. Head and neck pathology. 2017;11(4):519-24. https://doi.org/10.1007/s12105-016-0767-9.
 
[13] Damm DD, White DK, Drummond JF, Poindexter JB, Henry BB. Combined epithelial odontogenic tumor: adenomatoid odontogenic tumor and calcifying epithelial odontogenic tumor. Oral Surgery, Oral Medicine, Oral Pathology. 1983;55(5):487-96. https://doi.org/10.1016/0030-4220(83)90235-9.
[14] Bingham RA, Adrian JC. Combined epithelial odontogenic tumor—adenomatoid odontogenic tumor and calcifying epithelial odontogenic tumor: report of a case. Journal of oral and maxillofacial surgery. 1986;44(7):574-7. https://doi.org/10.1016/S0278-2391(86)80101-X.
[15] Siar CH, Ng KH. Combined calcifying epithelial odontogenic tumor and adenomatoid odontogenic tumor. International journal of oral and maxillofacial surgery. 1987;16(2):214-6. https://doi.org/10.1016/S0901-5027(87)80133-9.
[16] Okada Y, Mochizuki K, Sugimura M, Noda Y, Mori M. Odontogenic tumor with combined characteristics of adenomatoid odontogenic and calcifying epithelial odontogenic tumors. Pathology, research and practice. 1987;182(5):647-57.
[17] Miyake M, Nagahata S, Nishihara J, Ohbayashi Y. Combined adenomatoid odontogenic tumor and calcifying epithelial odontogenic tumor: report of case and ultrastructural study. Journal of oral and maxillofacial surgery. 1996;54(6):788-93. https://doi.org/10.1016/S0278-2391(96)90706-5.
[18] Takeda Y, Kudo K. Adenomatoid odontogenic tumor associated with calcifying epithelial odontogenic tumor. International journal of oral and maxillofacial surgery. 1986;15(4):469-73. https://doi.org/10.1016/S0300-9785(86)80040-0.
[19] Siar CH, Ng KH. The combined epithelial odontogenic tumour in Malaysians. British Journal of Oral and Maxillofacial Surgery. 1991;29(2):106-9. https://doi.org/10.1016/0266-4356(91)90093-K.
[20] Ledesma CM, Taylor AM, de León ER, de la Piedra Garza M, Jaukin PG, Robertson JP. Adenomatoid odontogenic tumour with features of calcifying epithelial odontogenic tumour.(The so-called combined epithelial odontogenic tumour.) Clinico-pathological report of 12 cases. European Journal of Cancer Part B: Oral Oncology. 1993;29(3):221-4. https://doi.org/10.1016/0964-1955(93)90026-B.