Document Type : Review Article
Department of Internal Medicine, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Medical Center of Digestive Disease, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China
School of Medicine, Capital Medical University, Beijing, China
Department of Internal Medicine, School of Medicine, Bandarabbas University of Medical Sciences, Hormozgan, Iran
Department of Cardiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Background and aim: Prevalence malignancy and COPD in the patients infected by COVID-19 has been considered to be of high importance for the health-care laborers. Therefore, the present systematic review and meta-analysis aimed to determine the malignancy prevalence and the chronic obstructive pulmonary disease amongst COVID-19 patients.
Materials and methods: Some electronic databases, PubMed, Cochrane Library, Embase, and ISI have been used to perform systematic literature in May 2020. Then, a software program (Endnote X8) has been utilized for managing the electronic titles. Two reviewers blind and independently extracted data from abstracts and full-text studies. Moreover, the prevalence of malignancies and COPD with 95% CI has been estimated via the inverse variance method and fix effect model of meta-analysis. Also, heterogeneity has been assessed with I2 and Chi-square. Consequently, forest plots and Funnel plot have been evaluated with the use of a software program (i.e., Comprehensive Meta-Analysis Stata V16).
Results: A total of 167 potentially relevant titles and abstracts have been found during the electronic and manual search. Finally, ten studies have been included. Prevalence of Malignancy equalled 1.56%, effect size has been (ES 2.04 95% CI -61.03, 65.11. P= 0.95) among the six studies and the total number of patients has been 1595 (915 men, 680 female) with the age range of 20-68 years. No statistically significant difference has been found between studies (p=1.00).
Conclusion: It has been found that malignancy and chronic obstructive pulmonary disease are the most pervasive underlying diseases in patients with COVID-19.