Aortic Remodeling and Human Immunodeficiency Virus Infection: Two Case Reports

Document Type : Case Reports


1 Department of Cardiology, Teaching University Hospital of Brazzaville, Brazzaville, Republic of Congo

2 Department of Cardiology, Health Science Faculty, Marien Ngouabi University, Brazzaville, Republic of Congo


The human immunodeficiency virus infection is a pathology responsible for chronic inflammation leading to vascular remodeling. We report two cases of patients living with human immunodeficiency virus, with severe aortic insufficiency and dilation of the aorta. Heart failure dominated the clinical signs. The chest x-ray showed cardiomegaly and an enlarged mediastinum. Doppler echocardiography showed, in addition to severe aortic leakage, unusual dilation of the aorta and dissection of the ascending aorta in one of the patients. The computed tomography of the aorta revealed more details about the accuracy and extent of aortic lesions. One of the patients underwent surgical treatment.


Main Subjects

[1]  Leclercq P, Grenoble CH. L’infection VIH: une maladie chronique inflammatoire. Med Mal Infect. 2010;40:1-6.
[2]  Mirza H, Patel P, Suresh K, Krukenkamp I, Lawson WE. HIV disease and an atherosclerotic ascending aortic aneurysm. Reviews in cardiovascular medicine. 2004;5(3):176-81.
[3]  Lucas ML, Binotto Í, Behar P, Erling N, Lichtenfels E, Aerts N. Thoracoabdominal Aortic Aneurysm in a HIV-positive Patient. Brazilian journal of cardiovascular surgery. 2017;32(1):53-6.
[4]  Konin C, Amani A, Koffi J. dissection aortique et infection a vih, une association rare observee a l’institut de cardiologie d’abidjan (ICA). Rev. Int. Sc. Méd. Vol. 2009;11(2):72-4.
[5]  Moh DR, Badjé A, Ello NF, N'takpé JB, Anzouan-Kacou JB, Kouamé GM, et al. Dissection aortique anévrismale chez un adulte infecté par le VIH-1 dans le cadre d’un syndrome de reconstitution immune avec tuberculose. Pan African Medical Journal. 2018;31(1). doi:10.11604/pamj.2018.31.10.12824.
[6]  Silvestri V, D'Ettorre G, Borrazzo C, Mele R. Many different patterns under a common flag: aortic pathology in HIV—a review of case reports in literature. Annals of vascular surgery. 2019;59:268-84.
[7]  Jacomet C, Illes G, Kwiatkowski F, Vidal M, Mrozek N, Aumeran C, et al. Prevalence of aortic valve dystrophy and insufficiency in a cohort of 255 HIV-positive patients followed-up in a cardiology department between 2012 and 2014. International journal of cardiology. 2016;220:82-6.
[8]  Butt AA, Chang CC, Kuller L, Goetz MB, Leaf D, Rimland D, et al. Risk of heart failure with human immunodeficiency virus in the absence of prior diagnosis of coronary heart disease. Archives of internal medicine. 2011;171(8):737-43. doi:10.1001/archinternmed.2011.151.
[9]  Anzouan-Kacou JB, Dogoua P, Konin C, Coulibaly I, Ouattara I, Eholié SP, ET AL. Affections cardio-vasculaires chez les patients à sérologie VIH positive non traités par anti-rétroviraux. Cardiovascular diseases in HIV patients not receving antiretroviral therapy. Cardiologie tropicale. 2013;131:1-7.
Volume 3, Issue 4
December 2021
Pages 190-192
  • Receive Date: 14 September 2021
  • Revise Date: 04 November 2021
  • Accept Date: 18 November 2021
  • First Publish Date: 24 November 2021