Strategy for Treating the Gastric Cancer: A Systematic Review and Meta-analysis

Document Type : Review Article


1 Department of Internal Medicine, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

2 Department of Cardiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

3 School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

4 Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran


Background and aim: Contemporary approaches to treat the stage IV patients could be generally divided into five groups of the palliative gastrectomy, radiotherapy, Chemotherapy, bypass, and gastric stent. The present systematic review and meta-analysis evaluated the overall survival to treat stage IV gastric cancer (GC) based on distinct signs and prognosis.
Materials and methods: MEDLINE, PubMed, Cochrane Library, Embase, ISI, google scholar have been utilized as the electronic databases for searching systematic literature until 2019. Then, Endnote X9, which is one of the software programs in the market, has been applied to manage the titles electronically. Searches were performed with keywords, “Gastric cancer”, “cancer”,” Gastric”,” Stage IV”, “Radiotherapy” “Chemotherapy” , “Gastrectomy”, “treatment of gastric cancer”, “bypass”.
Results: A total of 150, 93, 21 studies respective abstracts and topics have been discovered in the course of manual and electronic searches in the internet. Finally, a total of 10 studies for Palliative gastrectomy, five studies for Chemotherapy, and three studies for Radiotherapy  required for this systematic review.
Conclusion: According to the meta-analysis, palliative gastrectomy exhibited a statistically significant survival advantage for the patients with the untreatable developed GC.


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