Tehran: International Journal of Scientific Research in Dental and Medical Sciences International Journal of Scientific Research in Dental and Medical Sciences 2676-5497 7 3 2025 09 01 Comparison of the Effect of Two Sodium Hypochlorite Concentrations on Micro-hardness of Butterfly-shaped Sclerotic Dentin in Single-rooted Premolar Teeth 101 105 232336 10.30485/ijsrdms.2025.536625.1670 EN Yasamin Roghaa Department of Endodontics, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran 0009-0006-8829-7831 Parisa Ranjbarian Department of Endodontics, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran 0000-0001-9430-9284 Mehrzad Moazzam Department of Endodontics, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran 0009-0008-0351-6201 Journal Article 2025 07 20 Background and aim: Given the significance of the butterfly effect in premolars undergoing root canal treatment and their increased risk of vertical root fracture, it is important to investigate the impact of irrigation with different concentrations of sodium hypochlorite on premolar teeth with the butterfly effect. Material and methods: This experimental study evaluated 30 single-rooted premolar teeth with butterfly-shaped sclerotic dentin. The teeth with circular root sections were selected to ensure an equal mesiodistal-to-buccolingual width ratio. The roots were sectioned into coronal, middle, and apical thirds. Microhardness measurements were conducted on the buccal and mesial sides at four points within the middle third of each root. After specimen preparation, the samples were allocated into three groups: 0.9% normal saline (control), 2.5%, and 5% concentration of sodium hypochlorite (intervention). Microhardness was assessed before and after the intervention; data were recorded in the checklist, and statistical analysis was performed at the 0.05 significance level using SPSS 26. Results: The average microhardness of dentin with the butterfly effect in all groups, including 2.5% and 5% sodium hypochlorite and physiological saline, was less than before treatment. Sodium hypochlorite at the two investigated concentrations had a significantly greater effect than physiological saline (p<0.05), but there was no statistically significant difference between the two concentrations (p>0.05). Conclusions: Sodium hypochlorite at both 2.5% and 5.25% concentrations reduces the microhardness of dentin with a butterfly effect. A 2.5% concentration is recommended to minimize potential side effects.

http://www.ijsrdms.com/article_232336_f78361e9ff1bb0f1430103c65a504cbf.pdf

Tehran: International Journal of Scientific Research in Dental and Medical Sciences International Journal of Scientific Research in Dental and Medical Sciences 2676-5497 7 3 2025 09 01 Anti-Inflammatory Activity of Purified 36.3 kDa Coleus Aromatics Leaves Protein: An in Vitro Study 106 109 232338 10.30485/ijsrdms.2025.542501.1676 EN Santhosh Kumar Nune Department of Biochemistry, Prathima Relief Institute of Medical Sciences, Hanamkonda, Telangana, India 0000-0002-3741-7307 Alia Nusruth Department of Biochemistry, Adichunchanagiri Institute of Medical Sciences, Adichunchanagiri University, Karnataka, India Ramesh Babu Elle Department of Anatomy, Shridevi Institutes of Medical Sciences & Research Hospital, Tumkur, Karnataka, India Dinesha Ramadas Department of Biochemistry, Adichunchanagiri School of Natural Sciences, Adichunchanagiri University, Karnataka, India 0000-0002-8702-3357 Journal Article 2025 07 21 Background and aim: Medicinal plants have recently become the focus of intense study for conservation, as documented pharmacological effects support their traditional uses. This study aims to investigate the anti-inflammatory activity of purified 36.3 kDa Coleus aromaticus leaves protein (CALP) using the Human Red Blood Cells (HRBC) membrane stabilization method. Purified 36.3kDa CALP is used for this study. Material and methods: The HRBC membrane stabilization method was employed to investigate the anti-inflammatory activity of CALP. All data were expressed as mean ± standard deviation of three replicates (n=3). Results: The anti-inflammatory activity of the purified CALP was concentration-dependent; as the concentration increased, the percentage of protection also increased. The purified CALP shows a maximum anti-inflammatory activity of 65.93% (±3.12) at 500 μg/ml, which is slightly lower than that of the standard drug Diclofenac sodium [80.34% (±3.90)] at 200 μg/ml. The purified Coleus aromaticus leaves protein exhibits a membrane stabilization effect by inhibiting hypotonicity-induced lysis of erythrocyte membrane. Conclusions: This study concludes that the purified 36.6 kDa CALP exhibits a stronger membrane-stabilizing property than the standard drug Diclofenac sodium and thus has stronger anti-inflammatory activity. Proteins will continue to serve as a reservoir for the development of potent drugs with less severe and life-threatening adverse effects; however, these results need to be confirmed by in vivo anti-inflammatory studies.

http://www.ijsrdms.com/article_232338_c14637e121b001090d44353c5c8691dc.pdf

Tehran: International Journal of Scientific Research in Dental and Medical Sciences International Journal of Scientific Research in Dental and Medical Sciences 2676-5497 7 3 2025 09 01 Evaluating the Effect of Metal Nanoparticles in the Treatment of Peri-implantitis: A Systematic Review and Meta-analysis 110 116 227043 10.30485/ijsrdms.2025.538322.1673 EN Shima Firouzi Department of Prosthodontics, School of Dentistry, Dental Research Center, Avicenna Institute of Clinical Sciences, Avicenna Health Research Institute, Hamadan University of Medical Sciences, Hamadan, Iran 0009-0001-5936-8737 Fatemeh Zahra Kalakijuybari Department of Prosthodontics, School of Dentistry, Babol University of Medical Sciences, Babol, Iran 0009-0001-0843-0262 Maryam Afrasiabi Independent Researcher, Tehran, Iran 0009-0000-4740-9549 Shakila Peymani Department of Oral and Maxillofacial Surgery, School of Dentistry, Alborz University of Medical mSciences, Karaj, Iran 0000-0003-0273-7041 Journal Article 2025 06 25 Background and aim: Plaque-related pathological conditions such as peri-implantitis (PI) affect the tissues surrounding dental implants and affect the survival of implants. Hence, treatment of PI is of great importance, but bacterial resistance has been observed with antibiotics. Hence, the use of nanoparticles has been proposed. The present study aimed to evaluate the effect of metal nanoparticles (silver nanoparticles) in the treatment of peri-implantitis. Material and methods: The international databases PubMed, EMBASE, and Web of Science were searched using keywords aligned with the study objective up to July 2025. Two blinded, independent authors reviewed all articles. STATA/MP. v17 (College Station, Texas, USA) was used to perform the analyses. Results: In the present study, fifteen in vitro studies were included. Antibacterial activity of AgNPs in dental implants was 60% (ES: 0.60; 95% CI, 0.54, 0.67). The effectiveness of AgNPs for the treatment of peri-implantitis was 73% (ES: 0.73; 95% CI, 0.66, 0.81). Conclusions: The present study showed acceptable effectiveness of silver nanoparticles' antibacterial activity and reduction of inflammatory factors in the treatment of PI.

http://www.ijsrdms.com/article_227043_fe99bf9e78c5b76613102009d9e9e94f.pdf

Tehran: International Journal of Scientific Research in Dental and Medical Sciences International Journal of Scientific Research in Dental and Medical Sciences 2676-5497 7 3 2025 09 01 Effects of Rapid Maxillary Expansion on Upper Airway Airflow Characteristics: A Systematic Review and Meta-analysis 117 119 230419 10.30485/ijsrdms.2025.528110.1662 EN Faeze Shams Department of Orthodontics, Faculty of Dentistry, Tehran Azad University of Medical Sciences, Tehran, Iran 0000-0002-4165-2203 Faezeh Niroumandfar Faculty of Dentistry, Isf. C, Islamic Azad University, Isfahan, Iran 0009-0007-7869-3192 Parisa Doroudgar Department of public health, UFR of medicine and paramedical professions, Clermont Auvergne University, France 0000-0002-3500-3995 Zahra Mardani Orthodontics Unit, Department of Plastic Surgery, Hospital and Burn Research Center, Iran University of Medical Sciences, Tehran, Iran 0009-0009-3111-3554 Shiva Safari Independent Researcher, Tehran, Iran 0000-0003-2553-5135 Journal Article 2025 06 03 Background and aim: After rapid maxillary expansion, there is evidence that nasal airflow resistance is reduced. In the developmental age, it is unclear how RME affects upper airway airflow characteristics. Therefore, the aim pf present study was to evaluate the effects of rapid maxillary expansion on upper airway airflow characteristics. Material and methods: The present systematic review and meta-analysis included three randomized clinical trials and sixteen cohort studies international databases, PubMed, Scopus, Web of Science, and Embase, from January 1, 2015 to May 10, 2025, using keywords aligned with the study objective. Data extracted included numbers of participants, mean age, gender, Midpalatal suture maturation stage, nasal septum deviation, Intervention, and upper airway assessment. For each study that included, the mean value of airway pressure, nasal cavity volume, nasopharyngeal volume, and oropharyngeal volume was calculated between before and after rapid maxillary expansion. The statistical analysis was performed with Stata/MP.v17 as fixed effect models. Results: A significant reduction of airway pressure was found after RME (MD = -152.25; 95%CI -154.59 Pa to -149.92 Pa; p<0.001). there was a significant increase in nasal cavity volume after RME compared before RME (MD = 1.88; 95%CI 1.82 to 1.95; p<0.001), mean differences of oropharyngeal volume was 0.87 (MD = 0.87; 95%CI 0.75 to 0.99; p<0.001), and mean differences of nasopharyngeal volume was 0.80 (MD = 0.80; 95%CI 0.73 to 0.88; p<0.001). Conclusions: In children of growing age, rapid maxillary expansion can be an effective method on upper airway airflow characteristics.

http://www.ijsrdms.com/article_230419_40914815f66daa8550bdc83f7d573e88.pdf

Tehran: International Journal of Scientific Research in Dental and Medical Sciences International Journal of Scientific Research in Dental and Medical Sciences 2676-5497 7 3 2025 09 01 Healing of Apical Periodontitis after Gentle Wave System Versus Ultrasonic Activation with Negative Pressure Irrigation: A Systematic Review and Meta-analysis 120 127 232341 10.30485/ijsrdms.2025.550551.1681 EN Samin Sedghi Dental and Periodontal Research Center, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran 0009-0006-1718-9710 Negar Karamzadeh Endodontist, Private Research Center, Bushehr, Iran 0009-0000-6069-2676 Sara Karami Amidabadi School of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran 0009-0000-6265-2037 Maryam Afrasiabi Independent Researcher, Tehran, Iran 0009-0000-4740-9549 Yeganeh Azimi School of Dentistry, Pirogov Russian National Research Medical University, Moscow, Russia 0009-0009-0659-734X Journal Article 2025 06 15 Background and aim: The use of modern methods for root canal disinfection and the improvement of apical periodontitis are of great importance. Therefore, the present Systematic Review and Meta-Analysis was conducted to investigate the Healing of Apical Periodontitis after the Gentle Wave System versus Ultrasonic Activation with Negative Pressure Irrigation. Material and methods: The international databases PubMed/Scopus, MEDLINE (Ovid), Cochrane Library, and Embase were searched using keywords aligned with the study objective, up to August 2025. Two blinded, independent authors reviewed all articles. STATA/MP.v17 (College Station, Texas, USA) was used to perform the analyses. Results: Based on the findings of 12 included studies, healing rates for Gentle Wave System was 97% (ES: 97% 95% CI= 95%, 99%; p=0.51; I2=0); the healing rates for Ultrasonic Activation was 77% (ES: 77% 95% CI=75%, 79%; p=0.01; I2=62.88); the healing rates for Negative Pressure Irrigation. was 82% (ES: 82% 95% CI=79%, 85%; p=0.05; I2=60.79). There was a statistically significant difference in healing rates among the groups, with the Gentle Wave System performing significantly better than both Negative Pressure Irrigation and Ultrasonic Activation (p < 0.001). Conclusions: Based on the present meta-analysis, the Gentle Wave System was found to be more effective than Negative Pressure Irrigation and Ultrasonic Activation in improving apical periodontitis.

http://www.ijsrdms.com/article_232341_b483865d891c40681525f72af1f82469.pdf

Tehran: International Journal of Scientific Research in Dental and Medical Sciences International Journal of Scientific Research in Dental and Medical Sciences 2676-5497 7 3 2025 09 01 Incidental Serous Tubal Intraepithelial Carcinoma: A Case Report 128 130 232332 10.30485/ijsrdms.2025.535597.1667 EN Prachi Arun Department of Pathology, Maharaja Agrasen Medical College, Agroha, India 0009-0006-3796-1202 Nikita Prasad Department of Pathology, Maharaja Agrasen Medical College, Agroha, India 0000-0002-0432-2547 Anu Sahjlan Department of Pathology, Maharaja Agrasen Medical College, Agroha, India 0009-0008-1699-3162 Anjum Bhukal Department of Pathology, Maharaja Agrasen Medical College, Agroha, India 0009-0002-6883-8507 Manika Yadav Department of Pathology, Maharaja Agrasen Medical College, Agroha, India 0000-0002-8045-0284 Aditi Baghla Department of Pathology, Maharaja Agrasen Medical College, Agroha, India Journal Article 2025 07 02 High-grade pelvic serous carcinoma (HGSC) is the most common type of pelvic cancer among females. Serous tubal intraepithelial carcinoma (STIC) is an established precursor of HGSC, albeit rare and underdiagnosed. Its incidence ranges from <0.01% to 3% in BRCA carriers or those with a strong family history of breast or ovarian cancer. A 32 32-year-old P2L2 female underwent bilateral tubectomy for family planning, with no known family history of cancer. Histopathological examination of the fallopian tube revealed unilateral STIC. Incidental STIC mandates prolonged follow-up. Diagnosing tubal precursor lesions (such as SCOUT, STIL, STIC) to HGSC is crucial in identifying at-risk patients. The SEE-FIM protocol, along with a low immunohistochemistry threshold, is recommended. Due to its rarity and challenging diagnostic criteria, a high degree of suspicion on the part of pathologists and adequate follow-up are essential to reduce morbidity and mortality.

http://www.ijsrdms.com/article_232332_bbccb145d5d8a0aebe6ae5f3fb31ca31.pdf

Tehran: International Journal of Scientific Research in Dental and Medical Sciences International Journal of Scientific Research in Dental and Medical Sciences 2676-5497 7 3 2025 09 01 Atypical and Varied Presentations of Ameloblastoma: A Case Series 131 134 232335 10.30485/ijsrdms.2025.534550.1671 EN Shilpi Rajiv Daveshwar Department of Dentistry, GMERS Medical College Himmatnagar, Gujarat, India 0000-0002-3025-180X Hiral Samir Shah Department of Pathology, Baroda Medical College, Gujarat, India 0009-0006-5352-8513 Meena Rajiv Daveshwar Department of Pathology, Baroda Medical College, Gujarat, India 0009-0008-0010-8827 Journal Article 2025 06 14 Ameloblastoma is a benign odontogenic tumor that exhibits local aggressiveness. Around 80% cases occur in the mandible, out of which the majority of cases are seen in the mandibular ramus region. Ameloblastoma presents as a non-symptomatic lesion and may be detected during routine radiographic examination. However, the diagnosis is confirmed by histopathological examination. In our case series, we report three cases of Ameloblastoma: one in the maxilla and two in the mandible, of which one was in the ramus region and the other in the anterior region. All lesions were confirmed by histopathological examination with immunohistochemical staining. Histologically, Ameloblastoma has multiple microscopic variants. In our study, we found a follicular variant in the maxilla, a desmoplastic variant in the mandibular ramus, and a follicular and plexiform (mixed) pattern in the anterior mandible. In all three cases, there were varied clinical and radiographic findings. Thus, histopathological examination is a crucial confirmatory tool for accurate diagnosis and effective treatment planning.

http://www.ijsrdms.com/article_232335_a7cfd00e9150ddcdbdc24282226e24fa.pdf

Tehran: International Journal of Scientific Research in Dental and Medical Sciences International Journal of Scientific Research in Dental and Medical Sciences 2676-5497 7 3 2025 09 01 Role of Sticky Bone in Regeneration of Bony Defects in Periodontitis: A Clinical Case Series 135 139 233199 10.30485/ijsrdms.2025.543786.1678 EN SHIJNA ASHRAF Department of periodontics, Government Dental College Kottayam, Kottayam, India 0009-0008-5058-7088 Jeswin Johnson Department of periodontics, Government Dental College Kottayam, Kottayam, India 0009-0009-6045-7727 Rekha P Radhakrishnan Department of periodontics, Government Dental College Kottayam, Kottayam, India 0000-0001-9858-4814 Baiju R Madhavan Department of periodontics, Government Dental College Kottayam, Kottayam, India 0000-0002-9682-3209 Neethu P Reghu Department of periodontics, Government Dental College Kottayam, Kottayam, India 0009-0000-3307-4784 Santhosh Kumar S Department of periodontics, Government Dental College Kottayam, Kottayam, India 0000-0002-7707-5727 Journal Article 2025 07 01 <span style="mso-ascii-font-family: 'Times New Roman'; mso-ascii-theme-font: major-bidi; mso-hansi-font-family: 'Times New Roman'; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: major-bidi; font-weight: normal;">Periodontitis leads to progressive destruction of periodontal structures, often necessitating regenerative interventions. Injectable Platelet-Rich Fibrin (i-PRF), combined with bone grafts to form "sticky bone", is emerging as a promising regenerative approach. Sticky bone was generated by preparing i-PRF through the centrifugation of 10 mL of autologous venous blood and mixing it with demineralized bone matrix (Osseograft) to obtain a moldable and cohesive graft complex. This fibrin matrix not only secured the graft particles but also provided a biologically active framework that facilitated cell migration, proliferation, and neovascularisation. Additionally, the gradual release of growth factors from i-PRF promotes enhanced angiogenesis, soft tissue repair, and bone regeneration. This case series reports on three patients with intrabony defects and furcation involvement who were treated using i-PRF-based sticky bone. The clinical and radiographic outcomes were assessed at follow-up visits. All cases demonstrated a significant reduction in probing depth, along with radiographic evidence of bone fill. Healing was uneventful, and results remained stable over time. Sticky bone is a promising, autologous biomaterial that supports effective and predictable periodontal regeneration.

http://www.ijsrdms.com/article_233199_840177e89bb26e877293aa9612f50dd6.pdf