Tehran: International Journal of Scientific Research in Dental and Medical Sciences International Journal of Scientific Research in Dental and Medical Sciences 2676-5497 3 4 2021 12 01 Assessing the Effects of L-PRF on the Peri-implant Soft and Hard Tissue Parameters in Immediate Implants: A Randomised Controlled Trial 156 160 139488 10.30485/ijsrdms.2021.301525.1186 EN Navneet Kour Department of Periodontology and Implantology, BRS Dental College and Hospital, Panchkula, Haryana, India 0000-0003-0438-6118 Surya Sharma Doctor of Dental Surgery, Jammu, India 0000-0002-9474-3926 Journal Article 2021 08 25 Background and aim: Platelet-rich fibrin is a healing biomaterial with greater potential for enhancing tissue and osseous healing and regeneration without inflammatory reactions and can be used alone or in combination with bone grafts to promote blood coagulation bone maturation and growth. Although the use of platelet-rich plasma in dentistry, enhancing peri-implant healing with immediate implants placement is not well authenticated. The main aim of this study is to assess the effect of Leukocyte-and Platelet-Rich Fibrin (L-PRF) on the peri-implant soft and hard tissue parameters in immediate implants. Materials and methods: The split-mouth, randomized controlled trial on 10 systematically healthy subjects with adequate and maintainable oral hygiene. Subjects were enrolled, and sites were specified. On one site, atraumatic extraction was followed by immediate implant placement, while at another site, atraumatic extraction was done, followed by immediate implant placement with L-PRF application. Patients were recalled after 1, 3, and 6 months to evaluate various parameters, including tissue biotype, whether thick or thin, radiographic radiolucency (present or absent), modified plaque index, modified sulcus bleeding index, probing depth. The data was compiled and evaluated with an ANOVA test with a significant p-value of 0.05. Results: Statistically significant values were observed in all the parameters evaluated after the surgical procedure at 1, 3, and 6-month intervals with immediate implant placement along with Leukocyte-and Platelet-Rich Fibrin (L-PRF) membrane in extraction sockets. Conclusion: Within the study's limitation, it can be concluded that L-PRF can be used as a therapeutic adjuvant in clinical conditions of one-stage single tooth implant placements.

http://www.ijsrdms.com/article_139488_0bdf4fd756828f32426845c851a3c548.pdf

Tehran: International Journal of Scientific Research in Dental and Medical Sciences International Journal of Scientific Research in Dental and Medical Sciences 2676-5497 3 4 2021 12 01 The Impact of Metabolic Syndrome on Clinical Outcome of COVID-19 Patients: A Retrospective Study 161 165 140721 10.30485/ijsrdms.2021.307324.1201 EN Aparjot Singh Department of Respiratory Medicine, Adesh Medical College and Hospital, Shahbad, India 0000-0002-9634-6035 Rajpreet Brar Department of Gastroenterology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Haryana, India 0000-0002-5392-7403 Amrit Virk Department of Community Medicine, Adesh Medical College and Hospital, Shahbad, India 0000-0002-9603-6870 Sanjay Kumar Verma Department of Tuberculosis and Respiratory Disease, Ganesh Shankar Vidyarthi Memorial Medical College, Kanpur, India 0000-0003-0866-3805 Journal Article 2021 09 18 Background and aim: The COVID-19 disease has a very high infectivity rate, and the spectrum of the disease symptoms varies from asymptomatic to severe cases of respiratory failure. Metabolic syndrome has been identified as an independent risk factor for severe COVID-19. We studied the relationship between hypertension, diabetes, and obesity, individually and together as a metabolic syndrome, with COVID-19 patients admitted to our hospital. Materials and methods: We conducted a retrospective observational study involving 204 hospitalized patients with COVID-19 at our tertiary care center. COVID-19 patients were divided into two cohorts, metabolic syndrome and non-metabolic syndrome, according to modified World Health Organization criteria. The outcomes of the analyses were hospital mortality, length of stay in the hospital, need for intensive care unit, invasive mechanical ventilation, and hospital readmissions. Results: The main finding of our study is that metabolic syndrome patients had significantly greater odds of having hospital mortality (OR=6.59 (2.98-14.55), p=0.025) and hospital readmission (OR=8.17 (1.572-42.51), p=0.013) respectively as compared to non-metabolic syndrome patients. Both hospital mortality and readmissions were regarded as predictors of the severity of COVID-19 disease. Conclusion: The COVID-19 patients with metabolic syndrome are more prone to hospital mortality and readmission than those with non-metabolic syndrome.

http://www.ijsrdms.com/article_140721_bc03040ec893396d15c13d0b69e3dba4.pdf

Tehran: International Journal of Scientific Research in Dental and Medical Sciences International Journal of Scientific Research in Dental and Medical Sciences 2676-5497 3 4 2021 12 01 Histopathological Effect of Arsenic in Drinking Water on Liver and Kidney of Albino Rat: A Light Microscopic Study 166 170 141371 10.30485/ijsrdms.2021.313575.1213 EN Prenika Shangloo Department of Anatomy, Government Medical College and Hospital, Jammu University, Jammu and Kashmir, India Bonita Gupte Department of Anatomy, Government Medical College and Hospital, Jammu University, Jammu and Kashmir, India 0000-0003-0965-4548 Midhat Syed Department of Anatomy, Government Medical College and Hospital, Jammu University, Jammu and Kashmir, India 0000-0002-0168-3670 Journal Article 2021 09 15 Background and aim: Arsenic is a common pollutant of water in developing counties, leads to major health problems, and affects all body organs. The current study aimed to evaluate the histopathological effects of arsenic on the liver and kidney of albino rats. Materials and methods: A total of 18 Wistar rats were divided into 3 groups (n = 6). The control group received only distilled water, ARS 50 Group received 50ppm of arsenic in drinking water as a daily oral dose for 4 weeks, and ARS 100 group received 100ppm of arsenic in drinking water as a daily oral dose, each day for 4 weeks. After experimentation, the rats were euthanized and tissues procured, treated, slides were prepared, and observational analysis was done. Results: The liver of rats exposed to low dose showed mild central venous dilatation and congestion, portal haemorrhage, and dilated portal vein. However, the liver of rats exposed to higher doses revealed distortion of tissue architecture, haemorrhage, necrosis, vacuolated cytoplasm, mononuclear infiltrate. These changes were more pronounced in the high dose group, and rats in the control group showed normal tissue architecture. The kidneys of rats exposed to arsenic revealed disrupted architecture, increased or decreased periglomerular space, eosinophilic casts, and mononuclear infiltrate in a dose-dependent manner compared to the control group, which revealed normal renal function architecture. Conclusion: According to the research results, even smaller doses of 50ppm of arsenic potentially induce pathological effects on the liver and kidney. Hence, the amount of arsenic should be checked in drinking water.

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Tehran: International Journal of Scientific Research in Dental and Medical Sciences International Journal of Scientific Research in Dental and Medical Sciences 2676-5497 3 4 2021 12 01 Elastic Properties of the Aorta Are Affected in Young Patients with Sleep Bruxism 171 178 141470 10.30485/ijsrdms.2021.315608.1216 EN Kader Eliz ŞAHİN Department of Cardiology, Adiyaman University Education and Research Hospital, Adiyaman, Turkey 0000-0002-4619-6630 Sezen Baglan Uzunget Department of Cardiology, Sincan State Hospital, Ankara, Turkey 0000-0001-7608-3592 Aydin Keskinruzgar Department of Maxillofacial Surgery, Faculty of Dentistry, Adiyaman University, Adiyaman, Turkey 0000-0001-5735-6890 Journal Article 2021 10 21 Background and aim: This study aimed to evaluate the effects of sleep bruxism (SB) on aortic elastic properties, which predict cardiovascular morbidity and mortality. Materials and methods: Twenty-eight patients (25 female, 3 male) with SB admitted to maxillofacial surgery outpatient clinic were enrolled in the study. The control group consisted of age and sex-matched 44 volunteers (9 female, 5 male) with no Bruxism complaints and normal orofacial examination findings. The two groups were compared in terms of aortic stiffness as measured by pulse wave velocity (PWV), aortic strain, and aortic distensibility. Results: Aortic strain and aortic distensibility were statistically significantly decreased in SB patients compared to the control group (p=0,006 and p=0,028 respectively), while PWV was increased in SB patients compared to the control group with a limited statistical significance (p=0.064). Correlation analysis revealed statistically significant positive associations between PWV and CRP level (r=0.281, p=0.017) and negative associations between aortic strain and distensibility with CRP level (r=-0.347, p=0.003 and r=-0.277, p=0.019, respectively). The diastolic function parameters, E/A, E/é mean, and E wave deceleration time, were within normal limits in SB patients, and we did not observe statistically significant differences among diastolic function parameters between two groups. Conclusion: Our study illustrated that aortic strain and aortic distensibility were decreased while PWV was increased in patients with SB. Further studies are required to further elucidate cardiovascular system manifestations in SB patients.

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Tehran: International Journal of Scientific Research in Dental and Medical Sciences International Journal of Scientific Research in Dental and Medical Sciences 2676-5497 3 4 2021 12 01 Analgesic Activity of Aqueous Extract of Solanum Xanthocarpum Berries (SXB) in Animal Models 179 183 141472 10.30485/ijsrdms.2021.315492.1214 EN Tarinita Devi Leisangthem Department of Pharmacology, Regional Institute of Medical Sciences, Imphal, India 0000-0003-4974-3633 Babycha Laishram Department of Pharmacology, Jawaharlal Nehru Institute of Medical Sciences, Imphal, India 0000-0002-8641-7434 Usham Dharmaraja Meetei Department of Pharmacology, Regional Institute of Medical Sciences, Imphal, India 0000-0003-3808-6615 Swagata Datta Department of Pharmacology, Regional Institute of Medical Sciences, Imphal, India 0000-0002-1582-8359 Journal Article 2021 10 17 Background and aim: Traditional medicines can be considered a reliable source of new drugs as they are safe, dependable, and cost-effective compared to synthetic drugs. Drugs that can alter pain sensitivity are known as analgesics, and many herbal products have this property. The purpose of this study was to see how effective an aqueous extract of Solanum xanthocarpum berries (SXB) is as an analgesic in animal models. Materials and methods: Analgesic activity was assessed using the tail-flick method (for central action) in rats and the acetic acid-induced writhing test (for peripheral action) in mice. Three doses of the plant extract (500, 1000, and 1500 mg/kg) prepared by dissolving the drugs in 2% gum acacia were used. The tail-flick method and the acetic acid-induced writhing test used standard pethidine 5 mg/kg and 100 mg/kg aspirin, respectively. The vehicle served as a controlled drug. Results: In the acetic acid-induced writhing test (p<0.001), the plant extract showed significant analgesic activity, while no analgesic activity was found in the tail-flick method. Conclusion: The aqueous extract of Solanum xanthocarpum berries exerts its analgesic activity through peripheral pain mechanism though it does not have any central action.

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Tehran: International Journal of Scientific Research in Dental and Medical Sciences International Journal of Scientific Research in Dental and Medical Sciences 2676-5497 3 4 2021 12 01 Scrotal Defects Reconstruction after Fournier's Gangrene 184 187 141476 10.30485/ijsrdms.2021.315745.1217 EN Afroza Nazneen Department of Burn and Plastic Surgery, School of Medicine, Rajshahi Medical College Hospital, Rajshahi, Bangladesh 0000-0003-3193-1871 Journal Article 2021 10 19 Background and aim: Fournier's gangrene is necrotizing fasciitis of the perineum and external genitalia. It involves the perianal area and scrotum. Adequate wound debridement, a broad-spectrum antibiotic, and fluid replacement therapy are all part of the treatment plan. After clinical stabilization, reconstruction can be planned secondarily. Materials and methods: Fifteen patients who underwent reconstruction after Fournier's gangrene in 2017 July to 2019 June at Burn and Plastic Surgery Department, Rajshahi Medical College Hospital, were analyzed retrospectively. All the patients were referred from General Surgery wards after completing initial management. Informed consent was obtained from all patients. Results: The most commonly used reconstructive methods were Scrotal advancement flaps, Pudendal thigh flap, medial thigh flap, Superomedial thigh flap. Penile wound coverage by split-thickness skin grafting was done in 03 cases. After reconstruction, the mean hospital stay was 5 days. 03 patients developed marginal flap necrosis (<5 mm), 5-10 mm tip necrosis in 02 cases and necrosis at three-point stitch area were in 03 cases. All the marginal necrosis and dehiscence areas healed conservatively. Due to negative suction drains, there were no Hematoma or Seroma complications. Conclusion: There is no perfect method for all patients. Instead, the ideal methodology is determined by the patient's age, expectations, and overall condition, defect characteristics, and the surgeon's experience.

http://www.ijsrdms.com/article_141476_0364816b2bcdae7877c8814a61f3db23.pdf

Tehran: International Journal of Scientific Research in Dental and Medical Sciences International Journal of Scientific Research in Dental and Medical Sciences 2676-5497 3 4 2021 12 01 Three-rooted Maxillary and Bi-rooted Mandibular Primary Canines: A Case Report 188 189 139125 10.30485/ijsrdms.2021.300821.1185 EN Khashayar Sanjari Department of Pediatric Dentistry, Dental School, Iran University of Medical Sciences, Tehran, Iran 0000-0001-5011-0927 Hosna Ebrahimi Zadeh Department of Restorative Dentistry, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran 0000-0002-8910-2745 Leila Eftekhar Department of Pediatric Dentistry, School of Dentistry, Alborz University of Medical Sciences, Karaj, Iran 0000-0001-6285-1511 Journal Article 2021 08 21 Multi-rooted primary canine is a rare anomaly in the primary dentition. The most common and normal form of root morphology in primary canines is a single root, while rare cases of bi-rooted or three-rooted canines have been reported in different ethnic groups. This anomaly is often discovered accidentally on routine radiographs. The anomaly often occurs bilaterally in the maxilla. This report presents a case of bilateral three rooted maxillary and unilateral bi-rooted mandibular primary canines in a four-year-old Iranian boy. This study aims to increase clinicians' awareness regarding this unique variation and emphasize the importance of radiological examination prior to root canal treatment.

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Tehran: International Journal of Scientific Research in Dental and Medical Sciences International Journal of Scientific Research in Dental and Medical Sciences 2676-5497 3 4 2021 12 01 Aortic Remodeling and Human Immunodeficiency Virus Infection: Two Case Reports 190 192 140764 10.30485/ijsrdms.2021.306038.1194 EN Jospin Karel Makani Bassakouahou Department of Cardiology, Teaching University Hospital of Brazzaville, Brazzaville, Republic of Congo 0000-0002-7831-6000 Christian Michel Kouala Landa Department of Cardiology, Health Science Faculty, Marien Ngouabi University, Brazzaville, Republic of Congo 0000-0003-2961-6071 Eric Gibrel Kimbally-Kaky Department of Cardiology, Health Science Faculty, Marien Ngouabi University, Brazzaville, Republic of Congo 0000-0001-9849-2805 Paterne Rog Bakekolo Department of Cardiology, Teaching University Hospital of Brazzaville, Brazzaville, Republic of Congo 0000-0001-6278-470X Bertrand Fikhaem Ellenga Mbolla Department of Cardiology, Health Science Faculty, Marien Ngouabi University, Brazzaville, Republic of Congo 0000-0001-5249-2391 Meo Stephane Ikama Department of Cardiology, Health Science Faculty, Marien Ngouabi University, Brazzaville, Republic of Congo 0000-0003-1918-3559 Journal Article 2021 09 14 The human immunodeficiency virus infection is a pathology responsible for chronic inflammation leading to vascular remodeling. We report two cases of patients living with human immunodeficiency virus, with severe aortic insufficiency and dilation of the aorta. Heart failure dominated the clinical signs. The chest x-ray showed cardiomegaly and an enlarged mediastinum. Doppler echocardiography showed, in addition to severe aortic leakage, unusual dilation of the aorta and dissection of the ascending aorta in one of the patients. The computed tomography of the aorta revealed more details about the accuracy and extent of aortic lesions. One of the patients underwent surgical treatment.

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