Tehran: International Journal of Scientific Research in Dental and Medical Sciences International Journal of Scientific Research in Dental and Medical Sciences 2676-5497 8 1 2026 03 01 Association of Multimodality Imaging Features with Breast Cancer Molecular Subtypes 25 32 250659 10.30485/ijsrdms.2026.593451.1711 EN Kiran Yadav Department of Radiodiagnosis, RNT Medical College, Udaipur, Rajasthan, India 0009-0003-8498-8713 Sushila Yadav Independent Researcher, Jaipur, Rajasthan, India 0009-0003-3995-1129 Rajesh Yadav Department of General Medicine, Government Medical College, Kota, Rajasthan, India 0009-0006-5245-3492 Kavita Yadav Independent Researcher, Jhalawar Medical College, Jhalawar, Rajasthan, India 0009-0004-5286-4289 Journal Article 2026 01 09 <strong>Background and aim: </strong>Breast cancer comprises distinct molecular subtypes with different biological characteristics and treatment responses. This study evaluated the association between multimodality imaging features and immunohistochemically defined breast cancer molecular subtypes.<br><strong>Material and methods: </strong>This cross-sectional observational study included 50 women with histopathologically confirmed breast cancer who underwent mammography, ultrasonography (USG), and contrast-enhanced magnetic resonance imaging (MRI) between October 2023 and December 2024. We assessed imaging features and correlated them with molecular subtypes. We evaluated associations using contingency tests and univariate logistic regression, and assessed diagnostic performance using receiver operating characteristic (ROC) analysis.<br><strong>Results: </strong>The mean age was 51.56 ± 10.3 years. Luminal A was the most frequent subtype (30%), followed by Luminal B (28%). Mammographic calcifications were more frequent in HER2-enriched tumors but were not significantly associated with this subtype (OR: 3.33, 95% CI: 0.62–18.0, p=0.162). Posterior acoustic enhancement was significantly associated with TNBC (OR: 20.9, 95% CI: 10.5–415, p<0.001; AUC=0.88), as was a circumscribed margin (OR: 18.75, 95% CI: 3.46–101.6, p<0.001; AUC=0.86). Posterior acoustic shadowing was associated with Luminal A (OR: 5.33, 95% CI: 1.27–22.32, p=0.035; AUC=0.69).<br><strong><span lang="EN-GB">Conclusions: </span></strong><span lang="EN-GB">Selected imaging features were associated with specific breast cancer molecular subtypes. Larger multicenter studies with integrated and validated predictive models are needed to confirm these findings.</span> http://www.ijsrdms.com/article_250659_b7288b84b464f0fc76d27109b243d084.pdf