Tehran: International Journal of Scientific Research in Dental and Medical Sciences International Journal of Scientific Research in Dental and Medical Sciences 2676-5497 7 3 2025 09 01 Role of Sticky Bone in Regeneration of Bony Defects in Periodontitis: A Clinical Case Series 135 139 233199 10.30485/ijsrdms.2025.543786.1678 EN SHIJNA ASHRAF Department of periodontics, Government Dental College Kottayam, Kottayam, India 0009-0008-5058-7088 Jeswin Johnson Department of periodontics, Government Dental College Kottayam, Kottayam, India 0009-0009-6045-7727 Rekha P Radhakrishnan Department of periodontics, Government Dental College Kottayam, Kottayam, India 0000-0001-9858-4814 Baiju R Madhavan Department of periodontics, Government Dental College Kottayam, Kottayam, India 0000-0002-9682-3209 Neethu P Reghu Department of periodontics, Government Dental College Kottayam, Kottayam, India 0009-0000-3307-4784 Santhosh Kumar S Department of periodontics, Government Dental College Kottayam, Kottayam, India 0000-0002-7707-5727 Journal Article 2025 07 01 <strong><span style="mso-ascii-font-family: 'Times New Roman'; mso-ascii-theme-font: major-bidi; mso-hansi-font-family: 'Times New Roman'; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: major-bidi; font-weight: normal;">Periodontitis leads to progressive destruction of periodontal structures, often necessitating regenerative interventions. Injectable Platelet-Rich Fibrin (i-PRF), combined with bone grafts to form "sticky bone", is emerging as a promising regenerative approach. Sticky bone was generated by preparing i-PRF through the centrifugation of 10 mL of autologous venous blood and mixing it with demineralized bone matrix (Osseograft) to obtain a moldable and cohesive graft complex. This fibrin matrix not only secured the graft particles but also provided a biologically active framework that facilitated cell migration, proliferation, and neovascularisation. Additionally, the gradual release of growth factors from i-PRF promotes enhanced angiogenesis, soft tissue repair, and bone regeneration. This case series reports on three patients with intrabony defects and furcation involvement who were treated using i-PRF-based sticky bone. The clinical and radiographic outcomes were assessed at follow-up visits. All cases demonstrated a significant reduction in probing depth, along with radiographic evidence of bone fill. Healing was uneventful, and results remained stable over time. Sticky bone is a promising, autologous biomaterial that supports effective and predictable periodontal regeneration.</span></strong> http://www.ijsrdms.com/article_233199_840177e89bb26e877293aa9612f50dd6.pdf