Tehran: International Journal of Scientific Research in Dental and Medical Sciences International Journal of Scientific Research in Dental and Medical Sciences 2676-5497 6 1 2024 02 15 Evaluate Enhanced Bone Regeneration by Human Adult Dental Pulp Stem Cells Combination with Scaffold: A Systematic Review and Meta-analysis 17 23 190345 10.30485/ijsrdms.2024.441841.1559 EN Sahar Raissi Department of Prosthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran 0000-0002-7148-3447 Mehrdad Barekatain Department of Operative Dentistry, Faculty of Dentistry, Islamic Azad University, Isfahan (Khorasgan) Branch, Isfahan, Iran 0000-0003-4354-1707 Nima Barekatain Faculty of Dentistry, Islamic Azad University, Isfahan (Khorasgan) Branch, Isfahan, Iran 0009-0004-4229-8594 Shirin Zahra Farhad Department of Periodontics, Faculty of Dentistry, Islamic Azad University, Isfahan (Khorasgan) Branch, Isfahan, Iran 0000-0003-2043-0860 Mahdi Khadematolrasoul Department of Periodontics, School of Dentistry, Centro Escolar University, Manila, Philippines 0009-0006-6467-7266 Sayeh Abbasnejad Endodontics Department, School of Dentistry, Islamic Azad University, Tehran, Iran 0009-0005-9751-3455 Journal Article 2023 12 04 <strong>Background and aim: </strong>The present study has tried to provide evidence in this field by summarizing the results of animal studies because comprehensive results can lead to the decision of clinical trials in this field. Therefore, the present study was conducted to evaluate enhanced bone regeneration by human adult dental pulp stem cells combined with scaffold.<br /><strong>Material and methods: </strong>The present study was conducted based on PRISMA 2020-27-item checklist by giving the keywords stem cells, scaffold, bone regeneration and human dental pulp stem cells, all articles available in the international databases PubMed, Web of Science, Scopus, Science Direct, Web of Knowledge, EBSCO, Wiley, ISI, Elsevier, Embase databases and Google Scholar search engine were reviewed until November 2023. STATA/MP. v17 software was used in this meta-analysis. Meta-analysis was performed using mean differences with 95% confidence interval in meta-analysis.<br /><strong>Results: </strong>According to meta-analysis, the mean difference in bone regeneration between the experimental and control groups was 1.69 (MD:1.69; 95% CI 1.00 – 2.39, P<0.001). According to meta-analysis, a statistically significant difference was observed considering different groups of scaffolds on bone regeneration in combination with DPSC/SHED (MD:4.84; 95% CI 4.72– 4.95, P<0.001).<br /><strong>Conclusions: </strong>The present meta-analysis showed that dental pulp stem cells, along with scaffold, can increase new bone formation and accelerate bone formation compared to the control group. http://www.ijsrdms.com/article_190345_7b6551ddd48ac100b1f651f83bdbdb2e.pdf